| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 96 | 31 | 31 | 6 | 14 | 3.80 | .302 | 1.27 | 8.4 | 3.0 | 7.8 | 210.2 | 197 | 96 | 89 | 16 | 70 | 181 | 3 | 0 | 0 | 1 | 18 | 6 | 6 | 3.35 |
| SP | Maddux, G.Maddux, Greg >> | 22 | 1988 | R | 37 | 30 | 30 | 8 | 16 | 4.23 | .324 | 1.43 | 9.7 | 3.2 | 5.4 | 210.2 | 226 | 110 | 99 | 20 | 75 | 127 | 3 | 0 | 0 | 0 | 15 | 2 | 2 | 4.13 |
| SP | Sutcliffe, R.Sutcliffe, Rick # >> | 28 | 1984 | R | 48 | 30 | 30 | 10 | 13 | 4.33 | .299 | 1.24 | 8.7 | 2.5 | 7.4 | 216.1 | 208 | 111 | 104 | 22 | 60 | 177 | 6 | 0 | 0 | 1 | 16 | 9 | 1 | 3.64 |
| SP | Taillon, J.Taillon, Jameson # >> | 31 | 2023 | R | 36 | 30 | 30 | 9 | 11 | 5.95 | .341 | 1.52 | 10.3 | 3.4 | 5.8 | 148.1 | 169 | 108 | 98 | 26 | 56 | 95 | 0 | 0 | 0 | 0 | 6 | 5 | 1 | 5.24 |
| SP | Jackson, D.Jackson, Danny >> | 30 | 1992 | L | 19 | 29 | 29 | 8 | 11 | 4.60 | .330 | 1.47 | 9.2 | 4.1 | 4.9 | 174.0 | 177 | 98 | 89 | 16 | 79 | 94 | 1 | 0 | 0 | 0 | 13 | 1 | 1 | 4.49 |
| RP | Darvish, Y.Darvish, Yu >> | 31 | 2018 | R | 17 | 76 | 0 | 11 | 5 | 4.10 | .347 | 1.58 | 8.8 | 5.4 | 8.7 | 138.1 | 135 | 70 | 63 | 12 | 83 | 133 | 0 | 8 | 6 | 0 | 0 | 3 | 3 | 4.07 |
| RP | Williams, M.Williams, Mitch >> | 25 | 1989 | L | 10 | 52 | 0 | 4 | 7 | 4.43 | .325 | 1.44 | 7.8 | 5.2 | 4.7 | 61.0 | 53 | 36 | 30 | 4 | 35 | 32 | 0 | 8 | 6 | 0 | 0 | 0 | 5 | 4.52 |
| RP | Wendell, T.Wendell, Turk >> | 30 | 1997 | R | 9 | 38 | 0 | 1 | 1 | 3.00 | .311 | 1.33 | 7.1 | 4.9 | 4.7 | 42.0 | 33 | 14 | 14 | 3 | 23 | 22 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 4.60 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 28 | 2004 | R | 14 | 20 | 0 | 1 | 1 | 2.57 | .337 | 1.52 | 8.1 | 5.6 | 6.9 | 21.0 | 19 | 6 | 6 | 2 | 13 | 16 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 4.57 |
| RP | Samardzija, J.Samardzija, Jeff >> | 26 | 2011 | R | 28 | 19 | 0 | 0 | 0 | 2.31 | .346 | 1.50 | 7.4 | 6.3 | 5.5 | 23.1 | 19 | 9 | 6 | 1 | 16 | 14 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 4.70 |
| RP | Assenmacher, P.Assenmacher, Paul >> | 30 | 1990 | L | 24 | 26 | 0 | 2 | 3 | 5.04 | .364 | 1.68 | 9.9 | 5.4 | 4.2 | 30.1 | 33 | 18 | 17 | 2 | 18 | 14 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 4.83 |