| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 21 | 21 | 7 | 9 | 2.76 | .262 | 1.04 | 7.0 | 2.5 | 10.5 | 143.2 | 111 | 45 | 44 | 15 | 39 | 167 | 1 | 0 | 0 | 1 | 16 | 3 | 2 | 2.91 |
| SP | Gausman, K.Gausman, Kevin # >> | 34 | 2025 | R | 82 | 21 | 21 | 5 | 4 | 3.85 | .298 | 1.23 | 8.9 | 2.2 | 9.1 | 135.2 | 134 | 61 | 58 | 10 | 33 | 137 | 0 | 0 | 0 | 0 | 12 | 6 | 3 | 2.80 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 58 | 20 | 20 | 1 | 8 | 6.19 | .377 | 1.75 | 11.7 | 4.1 | 9.3 | 80.0 | 104 | 56 | 55 | 11 | 36 | 83 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 4.25 |
| SP | Flaherty, J.Flaherty, Jack >> | 29 | 2025 | R | 53 | 22 | 20 | 7 | 7 | 5.45 | .340 | 1.52 | 10.0 | 3.8 | 9.4 | 102.1 | 113 | 64 | 62 | 19 | 43 | 107 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.65 |
| RP | Svanson, M.Svanson, Matt † >> | 26 | 2025 | R | 98 | 53 | 0 | 11 | 3 | 3.21 | .297 | 1.24 | 7.1 | 4.1 | 9.6 | 98.0 | 77 | 36 | 35 | 8 | 45 | 104 | 0 | 3 | 1 | 0 | 0 | 2 | 2 | 3.38 |
| RP | Fisher, B.Fisher, Braydon † >> | 24 | 2025 | R | 88 | 55 | 0 | 6 | 1 | 3.41 | .290 | 1.21 | 8.1 | 2.9 | 10.1 | 68.2 | 61 | 29 | 26 | 9 | 22 | 76 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 3.50 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 31 | 2025 | R | 74 | 43 | 0 | 2 | 2 | 3.76 | .325 | 1.42 | 8.5 | 4.5 | 9.3 | 52.2 | 49 | 25 | 22 | 4 | 26 | 54 | 0 | 3 | 3 | 0 | 0 | 1 | 3 | 3.48 |
| RP | Slaten, J.Slaten, Justin >> | 27 | 2025 | R | 62 | 42 | 0 | 3 | 4 | 5.40 | .353 | 1.60 | 10.1 | 4.3 | 8.3 | 55.0 | 62 | 35 | 33 | 8 | 26 | 51 | 0 | 5 | 3 | 0 | 0 | 2 | 0 | 4.56 |
| RP | Stewart, B.Stewart, Brock >> | 33 | 2025 | R | 54 | 40 | 0 | 5 | 3 | 4.53 | .297 | 1.25 | 8.3 | 3.1 | 9.9 | 49.2 | 45 | 25 | 25 | 7 | 17 | 54 | 0 | 0 | 6 | 0 | 0 | 1 | 1 | 3.76 |
| SP | Civale, A.Civale, Aaron >> | 30 | 2025 | R | 41 | 33 | 0 | 3 | 4 | 6.47 | .353 | 1.60 | 11.8 | 2.8 | 9.3 | 55.2 | 72 | 40 | 40 | 11 | 17 | 57 | 0 | 9 | 4 | 0 | 0 | 2 | 0 | 4.56 |