| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 28 | 28 | 14 | 5 | 3.18 | .288 | 1.18 | 8.2 | 2.4 | 11.1 | 181.0 | 165 | 65 | 64 | 20 | 48 | 223 | 2 | 0 | 0 | 2 | 17 | 7 | 3 | 2.88 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 80 | 28 | 28 | 4 | 13 | 5.40 | .329 | 1.44 | 10.2 | 2.9 | 11.2 | 163.1 | 184 | 102 | 98 | 32 | 52 | 202 | 0 | 0 | 0 | 0 | 10 | 4 | 6 | 4.10 |
| SP | Horton, C.Horton, Cade # >> | 23 | 2025 | R | 77 | 27 | 27 | 13 | 8 | 3.41 | .270 | 1.10 | 7.4 | 2.5 | 7.7 | 150.1 | 124 | 63 | 57 | 15 | 41 | 129 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 3.44 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 58 | 26 | 26 | 4 | 13 | 6.03 | .350 | 1.58 | 10.1 | 4.1 | 9.4 | 109.0 | 122 | 76 | 73 | 23 | 50 | 114 | 0 | 0 | 0 | 0 | 1 | 4 | 2 | 5.14 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 90 | 0 | 6 | 6 | 3.94 | .326 | 1.40 | 8.8 | 3.8 | 9.2 | 107.1 | 105 | 47 | 47 | 10 | 45 | 109 | 0 | 3 | 1 | 0 | 0 | 6 | 0 | 3.61 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 79 | 72 | 0 | 6 | 2 | 4.16 | .313 | 1.32 | 8.6 | 3.3 | 9.6 | 93.0 | 89 | 45 | 43 | 12 | 34 | 99 | 0 | 0 | 2 | 0 | 0 | 4 | 1 | 3.77 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 31 | 2025 | R | 74 | 71 | 0 | 3 | 4 | 3.96 | .313 | 1.30 | 7.5 | 4.2 | 8.3 | 86.1 | 72 | 44 | 38 | 10 | 40 | 79 | 0 | 2 | 1 | 0 | 0 | 6 | 4 | 4.28 |
| CL | Hader, J.Hader, Josh † >> | 31 | 2025 | L | 100 | 72 | 0 | 3 | 5 | 3.20 | .293 | 1.23 | 7.3 | 3.9 | 10.0 | 78.2 | 63 | 30 | 28 | 8 | 34 | 87 | 0 | 30 | 3 | 0 | 0 | 1 | 9 | 3.45 |
| SU | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 74 | 0 | 2 | 6 | 3.43 | .282 | 1.14 | 7.6 | 2.7 | 9.6 | 86.2 | 73 | 35 | 33 | 12 | 26 | 92 | 0 | 4 | 7 | 0 | 0 | 3 | 1 | 3.69 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 65 | 26 | 24 | 7 | 9 | 6.03 | .348 | 1.58 | 9.4 | 4.9 | 8.3 | 119.1 | 124 | 83 | 80 | 20 | 65 | 110 | 0 | 0 | 0 | 0 | 6 | 2 | 6 | 5.03 |