| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 38 | 38 | 19 | 11 | 3.29 | .284 | 1.16 | 8.3 | 2.1 | 10.9 | 243.1 | 225 | 93 | 89 | 23 | 58 | 294 | 0 | 0 | 0 | 0 | 25 | 6 | 1 | 2.60 |
| SP | Crochet, G.Crochet, Garrett # >> | 26 | 2025 | L | 89 | 37 | 37 | 18 | 9 | 3.78 | .284 | 1.15 | 8.3 | 2.0 | 10.4 | 231.0 | 214 | 99 | 97 | 34 | 52 | 267 | 3 | 0 | 0 | 0 | 23 | 9 | 6 | 3.39 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 79 | 35 | 35 | 14 | 11 | 3.74 | .326 | 1.41 | 9.0 | 3.7 | 6.9 | 194.2 | 194 | 84 | 81 | 20 | 80 | 148 | 0 | 0 | 0 | 0 | 18 | 8 | 4 | 4.18 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 65 | 34 | 34 | 12 | 9 | 4.68 | .327 | 1.44 | 8.1 | 4.9 | 10.6 | 171.1 | 154 | 92 | 89 | 25 | 93 | 201 | 1 | 0 | 0 | 1 | 12 | 3 | 8 | 4.23 |
| SP | Bello, B.Bello, Brayan # >> | 26 | 2025 | R | 55 | 31 | 31 | 8 | 9 | 5.11 | .344 | 1.54 | 9.5 | 4.4 | 7.6 | 160.1 | 168 | 91 | 91 | 27 | 79 | 135 | 0 | 0 | 0 | 0 | 10 | 5 | 3 | 5.08 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 98 | 0 | 3 | 1 | 2.94 | .267 | 1.08 | 7.3 | 2.5 | 8.3 | 98.0 | 79 | 33 | 32 | 11 | 27 | 90 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.48 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 102 | 0 | 4 | 0 | 1.92 | .260 | 1.00 | 6.4 | 2.7 | 8.7 | 79.2 | 56 | 18 | 17 | 3 | 24 | 76 | 0 | 1 | 0 | 0 | 0 | 4 | 2 | 2.63 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 81 | 0 | 3 | 1 | 2.10 | .258 | 1.01 | 5.4 | 3.8 | 7.4 | 55.2 | 33 | 14 | 13 | 2 | 23 | 45 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.20 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 69 | 0 | 11 | 2 | 1.95 | .257 | 1.00 | 5.1 | 3.9 | 5.6 | 69.1 | 39 | 15 | 15 | 5 | 30 | 43 | 0 | 3 | 1 | 0 | 0 | 3 | 0 | 4.13 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 50 | 0 | 5 | 2 | 4.10 | .271 | 1.08 | 7.5 | 2.3 | 7.9 | 48.1 | 40 | 22 | 22 | 5 | 12 | 42 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.48 |
| SU | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 63 | 0 | 2 | 3 | 3.38 | .281 | 1.09 | 6.9 | 3.0 | 8.0 | 64.0 | 49 | 24 | 24 | 8 | 21 | 57 | 0 | 4 | 6 | 0 | 0 | 5 | 0 | 4.06 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 74 | 0 | 7 | 4 | 1.96 | .259 | 1.05 | 5.1 | 4.4 | 10.6 | 78.0 | 44 | 17 | 17 | 3 | 38 | 92 | 0 | 46 | 2 | 0 | 0 | 0 | 6 | 2.60 |