| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 26 | 26 | 12 | 9 | 3.24 | .289 | 1.17 | 8.8 | 1.7 | 10.3 | 158.1 | 155 | 62 | 57 | 14 | 30 | 180 | 0 | 0 | 0 | 0 | 17 | 8 | 0 | 2.59 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 25 | 25 | 10 | 9 | 4.47 | .326 | 1.41 | 9.8 | 2.9 | 9.4 | 141.0 | 153 | 71 | 70 | 24 | 46 | 147 | 1 | 0 | 0 | 0 | 13 | 6 | 3 | 4.23 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 79 | 25 | 25 | 9 | 8 | 3.88 | .308 | 1.29 | 8.7 | 2.9 | 7.1 | 139.1 | 135 | 62 | 60 | 18 | 45 | 110 | 0 | 0 | 0 | 0 | 11 | 6 | 4 | 4.20 |
| SP | Glasnow, T.Glasnow, Tyler † >> | 31 | 2025 | R | 87 | 24 | 24 | 11 | 3 | 2.50 | .295 | 1.21 | 6.1 | 4.8 | 10.7 | 126.0 | 86 | 35 | 35 | 10 | 67 | 150 | 0 | 0 | 0 | 0 | 10 | 5 | 4 | 3.37 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 24 | 24 | 11 | 5 | 4.87 | .320 | 1.35 | 9.3 | 2.9 | 10.9 | 122.0 | 126 | 66 | 66 | 14 | 39 | 148 | 1 | 0 | 0 | 0 | 11 | 7 | 1 | 3.20 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 67 | 0 | 7 | 1 | 2.37 | .257 | 0.99 | 5.4 | 3.6 | 10.0 | 83.2 | 50 | 23 | 22 | 3 | 33 | 92 | 0 | 1 | 1 | 0 | 0 | 4 | 0 | 2.59 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 64 | 0 | 2 | 1 | 1.93 | .287 | 1.18 | 6.6 | 4.1 | 6.9 | 79.1 | 58 | 18 | 17 | 4 | 36 | 61 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.56 |
| RP | Hamilton, I.Hamilton, Ian # >> | 30 | 2025 | R | 57 | 57 | 0 | 3 | 2 | 5.88 | .354 | 1.56 | 8.5 | 5.6 | 9.8 | 59.2 | 56 | 39 | 39 | 8 | 37 | 64 | 0 | 0 | 1 | 0 | 0 | 5 | 7 | 4.73 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 56 | 0 | 5 | 4 | 2.08 | .232 | 0.84 | 5.3 | 2.4 | 12.3 | 60.2 | 35 | 15 | 14 | 2 | 16 | 82 | 0 | 29 | 2 | 0 | 0 | 4 | 3 | 1.70 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 52 | 0 | 2 | 2 | 1.58 | .275 | 1.12 | 6.0 | 4.1 | 7.9 | 57.0 | 38 | 10 | 10 | 4 | 26 | 50 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.58 |