| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 18 | 18 | 5 | 11 | 4.45 | .313 | 1.32 | 9.2 | 2.8 | 10.4 | 111.1 | 113 | 56 | 55 | 13 | 34 | 128 | 0 | 0 | 0 | 0 | 11 | 5 | 0 | 3.27 |
| SP | Brown, H.Brown, Hunter >> | 26 | 2025 | R | 91 | 17 | 17 | 7 | 1 | 4.31 | .325 | 1.40 | 8.8 | 3.8 | 9.6 | 100.1 | 98 | 48 | 48 | 11 | 42 | 107 | 0 | 0 | 0 | 0 | 8 | 5 | 0 | 3.70 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 80 | 16 | 16 | 1 | 8 | 7.36 | .345 | 1.55 | 10.0 | 4.0 | 9.0 | 69.2 | 77 | 59 | 57 | 17 | 31 | 69 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 5.64 |
| SP | Luzardo, J.Luzardo, Jesus † >> | 27 | 2025 | L | 64 | 16 | 16 | 9 | 2 | 3.52 | .305 | 1.30 | 8.5 | 3.2 | 9.3 | 92.0 | 87 | 37 | 36 | 11 | 33 | 95 | 1 | 0 | 0 | 1 | 8 | 1 | 2 | 3.60 |
| SP | Littell, Z.Littell, Zack # >> | 29 | 2025 | R | 60 | 18 | 16 | 3 | 5 | 5.76 | .352 | 1.56 | 10.9 | 3.1 | 7.8 | 89.0 | 108 | 57 | 57 | 17 | 31 | 77 | 0 | 1 | 0 | 0 | 3 | 6 | 1 | 5.00 |
| RP | Weaver, L.Weaver, Luke >> | 31 | 2025 | R | 85 | 42 | 0 | 3 | 2 | 2.98 | .258 | 1.03 | 6.1 | 3.1 | 9.7 | 63.1 | 43 | 21 | 21 | 5 | 22 | 68 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 2.97 |
| RP | Kinley, T.Kinley, Tyler † >> | 34 | 2025 | R | 61 | 45 | 0 | 6 | 3 | 2.97 | .285 | 1.20 | 8.4 | 2.5 | 9.9 | 57.2 | 53 | 20 | 19 | 4 | 16 | 63 | 0 | 5 | 2 | 0 | 0 | 0 | 3 | 2.54 |
| RP | Koenig, J.Koenig, Jared >> | 31 | 2025 | L | 57 | 22 | 0 | 2 | 3 | 2.89 | .294 | 1.18 | 8.4 | 2.3 | 9.6 | 28.0 | 26 | 9 | 9 | 3 | 7 | 30 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 3.21 |
| RP | Herget, J.Herget, Jimmy >> | 31 | 2025 | R | 53 | 18 | 0 | 0 | 0 | 4.57 | .330 | 1.43 | 9.0 | 4.3 | 11.1 | 21.2 | 21 | 11 | 11 | 5 | 10 | 26 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5.19 |