| SP | Tiant, L.Tiant, Luis $$ >> | 28 | 1968 | R | 97 | 22 | 22 | 10 | 5 | 4.94 | .297 | 1.26 | 7.8 | 3.6 | 8.4 | 125.2 | 108 | 69 | 69 | 23 | 50 | 116 | 4 | 0 | 0 | 2 | 9 | 1 | 2 | 4.76 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 21 | 21 | 11 | 6 | 3.49 | .261 | 1.04 | 7.1 | 2.3 | 5.1 | 141.2 | 112 | 56 | 55 | 18 | 36 | 80 | 6 | 0 | 0 | 3 | 13 | 2 | 3 | 4.33 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 21 | 21 | 9 | 6 | 4.32 | .297 | 1.24 | 7.9 | 3.3 | 6.0 | 145.2 | 127 | 70 | 70 | 20 | 53 | 96 | 6 | 0 | 0 | 0 | 11 | 5 | 5 | 4.67 |
| SP | Reulbach, E.Reulbach, Ed † $$ >> | 24 | 1906 | R | 60 | 20 | 20 | 13 | 5 | 3.38 | .279 | 1.14 | 6.6 | 3.7 | 3.7 | 133.1 | 98 | 52 | 50 | 5 | 54 | 54 | 3 | 0 | 0 | 3 | 12 | 3 | 0 | 3.96 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 21 | 20 | 5 | 7 | 5.89 | .340 | 1.54 | 10.5 | 3.4 | 4.0 | 110.0 | 128 | 73 | 72 | 22 | 41 | 49 | 1 | 0 | 0 | 1 | 9 | 1 | 3 | 5.85 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 51 | 0 | 4 | 4 | 2.73 | .268 | 1.09 | 6.0 | 3.9 | 9.3 | 62.2 | 41 | 20 | 19 | 4 | 27 | 64 | 0 | 24 | 4 | 0 | 0 | 1 | 0 | 3.13 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 41 | 0 | 1 | 0 | 2.70 | .272 | 1.12 | 7.7 | 2.3 | 11.3 | 50.0 | 43 | 17 | 15 | 7 | 13 | 63 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 3.08 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 35 | 0 | 4 | 2 | 4.86 | .302 | 1.27 | 7.3 | 4.1 | 6.6 | 37.0 | 30 | 23 | 20 | 4 | 17 | 27 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.41 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 34 | 0 | 1 | 0 | 3.03 | .261 | 1.06 | 6.2 | 3.6 | 9.2 | 38.2 | 26 | 13 | 13 | 2 | 15 | 39 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 2.82 |