| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 93 | 18 | 18 | 5 | 6 | 3.78 | .291 | 1.20 | 8.5 | 2.4 | 6.3 | 104.2 | 98 | 50 | 44 | 11 | 28 | 73 | 0 | 0 | 0 | 0 | 9 | 3 | 4 | 3.87 |
| SP | Snell, B.Snell, Blake $$ >> | 25 | 2018 | L | 80 | 16 | 16 | 10 | 3 | 3.43 | .299 | 1.26 | 7.1 | 4.3 | 8.0 | 97.0 | 76 | 37 | 37 | 8 | 46 | 86 | 0 | 0 | 0 | 0 | 9 | 2 | 2 | 3.78 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 16 | 16 | 7 | 7 | 4.07 | .312 | 1.33 | 9.7 | 2.3 | 4.4 | 135.0 | 146 | 66 | 61 | 17 | 34 | 66 | 11 | 0 | 0 | 1 | 6 | 4 | 2 | 4.50 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 16 | 16 | 5 | 6 | 3.90 | .311 | 1.35 | 8.0 | 4.1 | 7.3 | 113.0 | 101 | 50 | 49 | 13 | 51 | 92 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 4.25 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 41 | 0 | 5 | 5 | 2.59 | .289 | 1.22 | 7.7 | 3.4 | 10.0 | 55.2 | 47 | 16 | 16 | 3 | 21 | 61 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 2.64 |
| RP | Kuo, H.Kuo, Hong-Chih † >> | 29 | 2010 | L | 91 | 37 | 0 | 5 | 0 | 0.56 | .191 | 0.67 | 3.6 | 2.4 | 7.7 | 48.0 | 19 | 3 | 3 | 1 | 13 | 41 | 0 | 8 | 1 | 0 | 0 | 2 | 2 | 2.50 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 26 | 0 | 2 | 1 | 1.60 | .198 | 0.74 | 5.5 | 1.4 | 7.4 | 33.2 | 20 | 6 | 6 | 1 | 5 | 27 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 2.21 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 16 | 0 | 2 | 0 | 0.53 | .250 | 1.00 | 6.9 | 2.1 | 10.1 | 17.0 | 13 | 1 | 1 | 0 | 4 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.47 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 11 | 0 | 1 | 0 | 6.45 | .368 | 1.75 | 12.7 | 3.3 | 7.8 | 22.1 | 31 | 16 | 16 | 5 | 8 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.32 |