| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 19 | 19 | 5 | 5 | 4.01 | .278 | 1.11 | 7.4 | 2.6 | 8.8 | 128.0 | 105 | 59 | 57 | 14 | 37 | 125 | 0 | 0 | 0 | 0 | 12 | 6 | 0 | 3.48 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 18 | 18 | 2 | 6 | 5.84 | .353 | 1.61 | 11.9 | 2.6 | 7.1 | 89.1 | 118 | 62 | 58 | 16 | 26 | 70 | 0 | 0 | 0 | 0 | 3 | 2 | 4 | 4.71 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 18 | 18 | 5 | 11 | 4.77 | .321 | 1.39 | 8.3 | 4.3 | 4.9 | 137.2 | 127 | 82 | 73 | 10 | 65 | 74 | 4 | 0 | 0 | 2 | 8 | 3 | 1 | 4.36 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 18 | 18 | 8 | 5 | 3.97 | .331 | 1.47 | 11.0 | 2.3 | 5.5 | 133.2 | 162 | 60 | 59 | 14 | 34 | 82 | 3 | 0 | 0 | 0 | 11 | 2 | 1 | 3.95 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 18 | 18 | 6 | 10 | 6.32 | .352 | 1.58 | 11.4 | 2.8 | 4.5 | 114.0 | 145 | 84 | 80 | 16 | 35 | 57 | 4 | 0 | 0 | 1 | 6 | 6 | 2 | 4.90 |
| RP | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 49 | 0 | 7 | 2 | 2.84 | .259 | 1.04 | 6.3 | 3.1 | 8.0 | 66.2 | 46 | 21 | 21 | 5 | 23 | 59 | 0 | 5 | 4 | 0 | 0 | 1 | 2 | 3.29 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 42 | 0 | 4 | 2 | 3.35 | .300 | 1.25 | 6.8 | 4.6 | 5.9 | 53.2 | 40 | 20 | 20 | 3 | 27 | 35 | 0 | 6 | 3 | 0 | 0 | 2 | 3 | 4.06 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 21 | 0 | 2 | 0 | 2.79 | .237 | 0.93 | 6.2 | 2.2 | 11.5 | 29.0 | 20 | 9 | 9 | 5 | 7 | 37 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 3.41 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 19 | 0 | 2 | 4 | 3.21 | .279 | 1.13 | 6.0 | 4.4 | 3.5 | 33.2 | 22 | 12 | 12 | 1 | 16 | 13 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.15 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 61 | 17 | 0 | 1 | 0 | 2.35 | .378 | 1.83 | 10.2 | 6.6 | 1.2 | 15.1 | 17 | 4 | 4 | 0 | 11 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.93 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 3 | 0 | 1 | 1 | 1.80 | .211 | 0.80 | 3.6 | 3.6 | 5.4 | 5.0 | 2 | 1 | 1 | 1 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.60 |