| SP | Leonard, D.Leonard, Dutch # >> | 22 | 1914 | L | 91 | 15 | 15 | 8 | 3 | 3.35 | .255 | 1.00 | 7.2 | 1.8 | 5.1 | 107.1 | 86 | 43 | 40 | 11 | 21 | 61 | 3 | 0 | 0 | 2 | 9 | 3 | 1 | 3.87 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 15 | 15 | 9 | 3 | 4.30 | .317 | 1.38 | 8.7 | 3.7 | 7.1 | 104.2 | 101 | 50 | 50 | 10 | 43 | 82 | 3 | 0 | 0 | 1 | 8 | 2 | 6 | 3.97 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 7 | 4 | 5.21 | .308 | 1.30 | 9.2 | 2.6 | 5.7 | 102.0 | 104 | 60 | 59 | 14 | 29 | 65 | 0 | 0 | 0 | 0 | 7 | 3 | 4 | 4.45 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 15 | 15 | 4 | 7 | 5.76 | .296 | 1.25 | 8.9 | 2.4 | 8.5 | 106.1 | 105 | 70 | 68 | 17 | 28 | 100 | 2 | 0 | 0 | 0 | 5 | 1 | 2 | 4.02 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 14 | 14 | 5 | 5 | 3.99 | .299 | 1.25 | 8.0 | 3.2 | 5.4 | 97.0 | 86 | 45 | 43 | 11 | 35 | 58 | 2 | 0 | 0 | 1 | 7 | 3 | 1 | 4.45 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 69 | 28 | 0 | 4 | 1 | 1.17 | .233 | 0.91 | 5.1 | 3.1 | 6.3 | 23.0 | 13 | 8 | 3 | 1 | 8 | 16 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.22 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 21 | 0 | 1 | 1 | 4.96 | .319 | 1.41 | 10.7 | 2.3 | 10.1 | 16.1 | 19 | 9 | 9 | 2 | 4 | 18 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.13 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 21 | 0 | 0 | 1 | 6.43 | .373 | 1.71 | 10.3 | 5.1 | 7.7 | 14.0 | 16 | 10 | 10 | 3 | 8 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.00 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 38 | 0 | 2 | 2 | 5.11 | .373 | 1.78 | 12.8 | 3.8 | 9.0 | 24.2 | 34 | 14 | 14 | 7 | 10 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.04 |
| CL | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 31 | 0 | 1 | 3 | 4.91 | .333 | 1.47 | 9.3 | 4.0 | 7.8 | 29.1 | 30 | 16 | 16 | 2 | 13 | 25 | 0 | 17 | 2 | 0 | 0 | 1 | 1 | 3.62 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 4 | 0 | 2 | 0 | 3.78 | .333 | 1.50 | 11.8 | 2.3 | 5.1 | 16.2 | 21 | 7 | 7 | 1 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.44 |