| SP | Arrieta, J.Arrieta, Jake † # >> | 29 | 2015 | R | 100 | 39 | 39 | 19 | 12 | 2.73 | .256 | 1.01 | 6.6 | 2.5 | 8.4 | 310.0 | 226 | 96 | 94 | 18 | 86 | 288 | 11 | 0 | 0 | 5 | 27 | 8 | 5 | 2.81 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 80 | 38 | 38 | 21 | 10 | 3.12 | .294 | 1.24 | 7.0 | 4.1 | 5.3 | 274.0 | 213 | 104 | 95 | 16 | 126 | 162 | 2 | 0 | 0 | 0 | 28 | 3 | 3 | 3.99 |
| SP | Alexander, P.Alexander, Pete >> | 32 | 1919 | R | 84 | 37 | 37 | 15 | 14 | 3.78 | .294 | 1.22 | 8.6 | 2.4 | 4.9 | 299.2 | 286 | 137 | 126 | 15 | 79 | 164 | 16 | 0 | 0 | 5 | 19 | 9 | 3 | 3.44 |
| SP | Prior, M.Prior, Mark # >> | 22 | 2002 | R | 54 | 34 | 34 | 19 | 8 | 4.61 | .319 | 1.39 | 9.3 | 3.2 | 9.3 | 211.0 | 218 | 110 | 108 | 20 | 76 | 219 | 0 | 0 | 0 | 0 | 18 | 3 | 2 | 3.28 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 99 | 85 | 0 | 7 | 5 | 3.12 | .300 | 1.28 | 6.2 | 5.3 | 9.2 | 104.0 | 72 | 37 | 36 | 3 | 61 | 106 | 0 | 8 | 4 | 0 | 0 | 1 | 7 | 3.13 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 95 | 76 | 0 | 3 | 2 | 1.87 | .286 | 1.20 | 6.1 | 4.8 | 8.9 | 81.2 | 55 | 25 | 17 | 6 | 43 | 80 | 0 | 9 | 3 | 0 | 0 | 0 | 3 | 3.58 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 54 | 24 | 0 | 5 | 1 | 3.51 | .238 | 0.94 | 6.5 | 2.2 | 8.6 | 25.2 | 18 | 10 | 10 | 4 | 6 | 24 | 0 | 7 | 0 | 0 | 0 | 0 | 1 | 3.88 |
| RP | Leiter, M.Leiter, Mark >> | 33 | 2024 | R | 53 | 9 | 0 | 2 | 2 | 3.38 | .333 | 1.50 | 5.6 | 7.9 | 10.1 | 8.0 | 5 | 3 | 3 | 0 | 7 | 9 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.38 |
| RP | Grimm, J.Grimm, Justin >> | 28 | 2017 | R | 27 | 8 | 0 | 1 | 1 | 4.91 | .421 | 2.18 | 10.3 | 10.3 | 12.9 | 7.1 | 8 | 4 | 4 | 0 | 8 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.57 |
| RP | Darvish, Y.Darvish, Yu >> | 31 | 2018 | R | 24 | 29 | 0 | 1 | 1 | 6.20 | .360 | 1.64 | 8.3 | 6.5 | 9.6 | 61.0 | 56 | 42 | 42 | 7 | 44 | 65 | 0 | 3 | 0 | 0 | 0 | 3 | 5 | 4.67 |