| SP | Martinez, P.Martinez, Pedro >> | 28 | 1999 | R | 84 | 33 | 33 | 10 | 11 | 4.66 | .317 | 1.38 | 9.8 | 2.7 | 8.2 | 203.0 | 220 | 112 | 105 | 22 | 60 | 185 | 2 | 0 | 0 | 2 | 16 | 3 | 8 | 3.52 |
| SP | Steele, E.Steele, Elmer >> | 22 | 1908 | R | 83 | 32 | 32 | 13 | 13 | 3.75 | .289 | 1.19 | 8.7 | 2.1 | 4.8 | 221.0 | 213 | 101 | 92 | 19 | 51 | 117 | 7 | 0 | 0 | 2 | 18 | 5 | 0 | 3.82 |
| SP | O'Brien, B.O'Brien, Buck >> | 29 | 1911 | R | 64 | 46 | 23 | 4 | 7 | 4.85 | .334 | 1.47 | 8.7 | 4.7 | 4.9 | 81.2 | 78 | 44 | 44 | 9 | 42 | 44 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 5.02 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 93 | 0 | 9 | 5 | 2.94 | .255 | 1.02 | 6.9 | 2.3 | 8.7 | 125.1 | 96 | 43 | 41 | 9 | 32 | 121 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 2.79 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 96 | 81 | 0 | 9 | 6 | 3.23 | .300 | 1.28 | 8.4 | 3.1 | 7.9 | 106.0 | 99 | 40 | 38 | 4 | 37 | 93 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.78 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 81 | 96 | 0 | 7 | 4 | 3.84 | .310 | 1.31 | 7.8 | 4.1 | 9.2 | 93.2 | 81 | 40 | 40 | 7 | 42 | 95 | 0 | 2 | 2 | 0 | 0 | 3 | 3 | 3.39 |
| RP | Workman, B.Workman, Brandon >> | 30 | 2019 | R | 75 | 77 | 0 | 2 | 3 | 3.38 | .309 | 1.33 | 6.8 | 5.2 | 11.0 | 69.1 | 52 | 26 | 26 | 2 | 40 | 84 | 0 | 6 | 2 | 0 | 0 | 1 | 4 | 2.72 |
| RP | Embree, A.Embree, Alan >> | 32 | 2002 | L | 50 | 76 | 0 | 3 | 1 | 2.75 | .266 | 1.08 | 5.9 | 3.8 | 7.8 | 75.1 | 49 | 23 | 23 | 6 | 32 | 65 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.63 |
| RP | Barnes, M.Barnes, Matt >> | 29 | 2019 | R | 35 | 70 | 0 | 7 | 3 | 4.31 | .326 | 1.41 | 7.5 | 5.3 | 9.3 | 64.2 | 53 | 34 | 31 | 7 | 38 | 66 | 0 | 7 | 4 | 0 | 0 | 3 | 8 | 4.28 |
| RP | Hernandez, D.Hernandez, Darwinzon >> | 22 | 2019 | L | 18 | 60 | 0 | 3 | 2 | 5.27 | .388 | 1.88 | 9.2 | 7.9 | 8.4 | 56.1 | 57 | 35 | 33 | 2 | 49 | 52 | 0 | 4 | 2 | 0 | 0 | 1 | 11 | 4.29 |
| SP | Whitlock, G.Whitlock, Garrett >> | 26 | 2022 | R | 50 | 34 | 27 | 2 | 10 | 5.58 | .323 | 1.40 | 9.8 | 2.9 | 6.9 | 88.2 | 96 | 55 | 55 | 9 | 28 | 67 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 3.86 |