| SP | Eovaldi, N.Eovaldi, Nathan >> | 35 | 2025 | R | 95 | 33 | 33 | 16 | 12 | 3.39 | .278 | 1.11 | 7.8 | 2.2 | 6.0 | 217.2 | 189 | 87 | 82 | 22 | 53 | 145 | 0 | 0 | 0 | 0 | 20 | 9 | 9 | 3.84 |
| SP | deGrom, J.deGrom, Jacob † >> | 37 | 2025 | R | 87 | 32 | 32 | 19 | 5 | 3.67 | .286 | 1.17 | 8.0 | 2.6 | 8.6 | 196.0 | 174 | 84 | 80 | 24 | 56 | 187 | 0 | 0 | 0 | 0 | 17 | 5 | 3 | 3.62 |
| SP | Darvish, Y.Darvish, Yu † # >> | 26 | 2013 | R | 65 | 32 | 32 | 19 | 4 | 3.58 | .300 | 1.26 | 7.6 | 3.7 | 8.3 | 213.2 | 181 | 87 | 85 | 25 | 88 | 196 | 2 | 0 | 0 | 0 | 20 | 6 | 3 | 4.01 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 100 | 90 | 0 | 9 | 7 | 3.06 | .272 | 1.09 | 6.7 | 3.1 | 8.5 | 135.1 | 101 | 46 | 46 | 9 | 47 | 128 | 0 | 12 | 4 | 0 | 0 | 4 | 0 | 3.10 |
| RP | Uehara, K.Uehara, Koji >> | 37 | 2012 | R | 94 | 67 | 0 | 0 | 3 | 3.19 | .257 | 1.04 | 7.1 | 2.4 | 10.1 | 84.2 | 66 | 31 | 30 | 9 | 22 | 94 | 0 | 13 | 3 | 0 | 0 | 0 | 2 | 2.94 |
| RP | Leclerc, J.Leclerc, Jose >> | 24 | 2018 | R | 93 | 43 | 0 | 5 | 2 | 2.14 | .284 | 1.17 | 5.1 | 5.5 | 10.6 | 46.1 | 26 | 11 | 11 | 2 | 28 | 54 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 3.11 |
| RP | Armstrong, S.Armstrong, Shawn >> | 34 | 2025 | R | 87 | 32 | 0 | 2 | 3 | 4.40 | .317 | 1.40 | 7.7 | 5.1 | 8.4 | 28.2 | 24 | 14 | 14 | 3 | 16 | 26 | 0 | 9 | 0 | 0 | 0 | 0 | 3 | 4.25 |
| RP | Soria, J.Soria, Joakim >> | 30 | 2014 | R | 67 | 33 | 0 | 2 | 1 | 3.15 | .259 | 1.03 | 6.8 | 2.5 | 6.8 | 40.0 | 30 | 15 | 14 | 6 | 11 | 30 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.35 |
| SP | Scherzer, M.Scherzer, Max >> | 39 | 2023 | R | 89 | 18 | 0 | 5 | 0 | 1.02 | .253 | 1.02 | 5.7 | 3.5 | 7.8 | 44.1 | 28 | 5 | 5 | 1 | 17 | 38 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.73 |