| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 21 | 21 | 6 | 13 | 4.22 | .304 | 1.30 | 8.4 | 3.2 | 8.1 | 158.0 | 148 | 82 | 74 | 19 | 57 | 143 | 6 | 0 | 0 | 1 | 10 | 2 | 4 | 3.87 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 21 | 21 | 7 | 10 | 4.51 | .287 | 1.19 | 9.0 | 1.8 | 8.6 | 147.2 | 147 | 77 | 74 | 28 | 29 | 140 | 4 | 0 | 0 | 1 | 11 | 2 | 2 | 4.20 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 20 | 20 | 7 | 6 | 5.79 | .365 | 1.69 | 11.2 | 4.0 | 4.4 | 110.1 | 137 | 78 | 71 | 17 | 49 | 54 | 0 | 0 | 0 | 0 | 7 | 4 | 3 | 5.47 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 20 | 20 | 6 | 8 | 3.49 | .325 | 1.42 | 7.6 | 5.3 | 4.5 | 131.1 | 110 | 59 | 51 | 10 | 77 | 66 | 2 | 0 | 0 | 0 | 14 | 3 | 2 | 4.82 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 51 | 0 | 6 | 2 | 2.75 | .287 | 1.18 | 7.5 | 3.1 | 9.6 | 72.0 | 60 | 23 | 22 | 8 | 25 | 77 | 0 | 6 | 4 | 0 | 0 | 2 | 0 | 3.43 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 49 | 0 | 3 | 4 | 3.16 | .271 | 1.10 | 8.3 | 1.7 | 6.7 | 62.2 | 57 | 22 | 22 | 7 | 12 | 46 | 0 | 9 | 1 | 0 | 0 | 1 | 1 | 3.61 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 35 | 0 | 3 | 2 | 3.22 | .274 | 1.13 | 7.6 | 2.7 | 4.9 | 50.1 | 42 | 19 | 18 | 5 | 15 | 27 | 0 | 4 | 2 | 0 | 0 | 0 | 1 | 4.12 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 53 | 18 | 0 | 4 | 0 | 2.67 | .283 | 1.19 | 7.7 | 3.0 | 5.7 | 27.0 | 23 | 8 | 8 | 2 | 9 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.70 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 6 | 0 | 0 | 1 | 9.39 | .452 | 2.48 | 23.1 | 1.3 | 5.1 | 7.2 | 18 | 8 | 8 | 1 | 1 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.14 |