| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 36 | 36 | 12 | 16 | 4.48 | .280 | 1.14 | 8.6 | 1.7 | 8.3 | 235.0 | 224 | 123 | 117 | 25 | 45 | 216 | 8 | 0 | 0 | 2 | 21 | 5 | 2 | 3.18 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 36 | 36 | 15 | 12 | 3.49 | .288 | 1.19 | 7.0 | 3.8 | 7.8 | 234.2 | 182 | 96 | 91 | 17 | 98 | 203 | 2 | 0 | 0 | 0 | 25 | 5 | 3 | 3.53 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 28 | 25 | 8 | 6 | 3.87 | .316 | 1.35 | 6.6 | 5.5 | 3.9 | 179.0 | 131 | 83 | 77 | 10 | 110 | 78 | 1 | 0 | 0 | 0 | 14 | 7 | 4 | 4.82 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 29 | 28 | 13 | 8 | 3.78 | .317 | 1.38 | 7.9 | 4.6 | 5.3 | 192.2 | 168 | 93 | 81 | 8 | 98 | 114 | 3 | 0 | 0 | 1 | 19 | 2 | 6 | 3.92 |
| CL | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 40 | 0 | 4 | 6 | 3.26 | .299 | 1.26 | 7.9 | 3.4 | 8.6 | 47.0 | 41 | 18 | 17 | 9 | 18 | 45 | 0 | 14 | 3 | 0 | 0 | 1 | 0 | 4.79 |
| SU | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 32 | 0 | 1 | 3 | 5.23 | .290 | 1.19 | 7.6 | 3.4 | 7.3 | 32.2 | 27 | 19 | 19 | 2 | 12 | 26 | 0 | 10 | 4 | 0 | 0 | 1 | 2 | 3.41 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 70 | 0 | 4 | 6 | 3.31 | .276 | 1.13 | 6.9 | 3.3 | 8.6 | 73.1 | 56 | 31 | 27 | 6 | 27 | 70 | 0 | 3 | 4 | 0 | 0 | 1 | 2 | 3.30 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 42 | 0 | 7 | 1 | 2.35 | .274 | 1.11 | 5.9 | 4.1 | 7.4 | 46.0 | 30 | 12 | 12 | 3 | 21 | 38 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.63 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 28 | 0 | 2 | 2 | 2.67 | .264 | 1.07 | 6.0 | 3.7 | 10.3 | 27.0 | 18 | 8 | 8 | 1 | 11 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 2.41 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 27 | 0 | 1 | 2 | 5.28 | .310 | 1.31 | 10.2 | 1.6 | 9.0 | 29.0 | 33 | 17 | 17 | 4 | 5 | 29 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Adams, M.Adams, Mike # >> | 31 | 2009 | R | 99 | 30 | 0 | 0 | 5 | 4.45 | .326 | 1.42 | 7.9 | 5.1 | 8.7 | 32.1 | 28 | 16 | 16 | 2 | 18 | 31 | 0 | 9 | 2 | 0 | 0 | 1 | 0 | 3.66 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 11 | 10 | 1 | 2 | 4.90 | .346 | 1.55 | 9.4 | 4.6 | 7.6 | 64.1 | 67 | 37 | 35 | 7 | 33 | 54 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 4.38 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 49 | 14 | 0 | 3 | 0 | 2.95 | .299 | 1.26 | 8.3 | 3.1 | 9.4 | 61.0 | 56 | 21 | 20 | 5 | 21 | 64 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.05 |