| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 27 | 27 | 13 | 11 | 4.39 | .279 | 1.14 | 7.9 | 2.3 | 7.7 | 196.2 | 173 | 97 | 96 | 18 | 51 | 168 | 4 | 0 | 0 | 1 | 14 | 4 | 1 | 3.32 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 83 | 26 | 26 | 12 | 9 | 3.57 | .268 | 1.08 | 7.7 | 2.1 | 4.9 | 199.1 | 170 | 86 | 79 | 15 | 46 | 109 | 3 | 0 | 0 | 0 | 18 | 3 | 4 | 3.62 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 26 | 26 | 6 | 11 | 4.88 | .331 | 1.48 | 9.7 | 3.7 | 5.0 | 158.2 | 170 | 94 | 86 | 23 | 65 | 88 | 0 | 0 | 0 | 0 | 13 | 1 | 2 | 5.03 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 77 | 0 | 5 | 3 | 2.84 | .255 | 1.03 | 6.2 | 3.0 | 10.1 | 98.1 | 68 | 34 | 31 | 9 | 33 | 110 | 0 | 12 | 2 | 0 | 0 | 0 | 0 | 2.96 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 62 | 0 | 5 | 1 | 4.28 | .316 | 1.38 | 9.1 | 3.3 | 7.2 | 80.0 | 81 | 38 | 38 | 5 | 29 | 64 | 0 | 7 | 2 | 0 | 0 | 1 | 1 | 3.34 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 34 | 0 | 3 | 2 | 5.90 | .392 | 1.93 | 9.6 | 7.8 | 10.9 | 29.0 | 31 | 20 | 19 | 3 | 25 | 35 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 4.52 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 1 | 1 | 1 | 0 | 6.43 | .447 | 2.43 | 12.9 | 9.0 | 3.9 | 7.0 | 10 | 5 | 5 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.14 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 57 | 6 | 0 | 1 | 1 | 9.45 | .474 | 2.70 | 16.5 | 10.5 | 1.5 | 6.2 | 11 | 7 | 7 | 1 | 7 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 8.33 |