| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 28 | 28 | 11 | 9 | 3.54 | .288 | 1.19 | 8.2 | 2.5 | 9.3 | 183.0 | 166 | 75 | 72 | 13 | 51 | 189 | 1 | 0 | 0 | 1 | 21 | 5 | 0 | 2.78 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 27 | 27 | 11 | 12 | 4.73 | .322 | 1.40 | 10.1 | 2.5 | 6.1 | 192.1 | 216 | 105 | 101 | 20 | 54 | 130 | 7 | 0 | 0 | 2 | 11 | 4 | 2 | 3.91 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 26 | 26 | 11 | 11 | 4.48 | .327 | 1.45 | 9.4 | 3.7 | 5.0 | 182.2 | 190 | 94 | 91 | 29 | 74 | 101 | 4 | 0 | 0 | 0 | 11 | 2 | 3 | 5.21 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 26 | 26 | 7 | 12 | 4.77 | .321 | 1.39 | 9.3 | 3.2 | 5.4 | 185.0 | 191 | 110 | 98 | 25 | 66 | 111 | 3 | 0 | 0 | 0 | 12 | 5 | 3 | 4.71 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 72 | 0 | 3 | 4 | 3.92 | .318 | 1.38 | 8.5 | 3.9 | 11.1 | 96.1 | 91 | 42 | 42 | 10 | 42 | 118 | 0 | 8 | 6 | 0 | 0 | 2 | 12 | 3.27 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 34 | 0 | 4 | 3 | 3.76 | .268 | 1.04 | 7.3 | 2.1 | 9.2 | 38.1 | 31 | 18 | 16 | 3 | 9 | 39 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 2.84 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 24 | 0 | 1 | 2 | 5.23 | .374 | 1.79 | 7.7 | 9.0 | 7.7 | 20.2 | 17 | 13 | 12 | 3 | 20 | 17 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 6.25 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 9 | 0 | 0 | 2 | 4.96 | .310 | 1.35 | 7.3 | 5.1 | 2.8 | 16.1 | 13 | 11 | 9 | 3 | 9 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.50 |