| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 8 | 8 | 4.21 | .321 | 1.39 | 8.4 | 4.1 | 8.6 | 143.1 | 134 | 70 | 67 | 18 | 65 | 137 | 0 | 0 | 0 | 0 | 8 | 4 | 4 | 4.17 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 26 | 26 | 12 | 5 | 3.73 | .263 | 1.04 | 7.7 | 1.7 | 7.6 | 156.2 | 133 | 67 | 65 | 23 | 30 | 131 | 1 | 0 | 0 | 1 | 14 | 5 | 6 | 3.91 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 25 | 25 | 7 | 6 | 4.87 | .329 | 1.46 | 8.2 | 5.1 | 6.7 | 112.2 | 102 | 62 | 61 | 14 | 63 | 83 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 4.86 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 68 | 0 | 5 | 3 | 2.77 | .261 | 1.02 | 6.1 | 3.1 | 9.6 | 97.1 | 66 | 31 | 30 | 15 | 33 | 103 | 0 | 5 | 2 | 0 | 0 | 4 | 0 | 4.03 |
| RP | Davis, W.Davis, Wade # >> | 29 | 2015 | R | 89 | 65 | 0 | 6 | 4 | 5.47 | .333 | 1.49 | 9.1 | 4.4 | 8.3 | 80.2 | 81 | 50 | 49 | 12 | 39 | 74 | 0 | 6 | 4 | 0 | 0 | 1 | 3 | 4.60 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 51 | 0 | 5 | 3 | 2.77 | .294 | 1.25 | 6.9 | 4.4 | 7.9 | 55.1 | 42 | 17 | 17 | 4 | 27 | 48 | 0 | 7 | 2 | 0 | 0 | 0 | 5 | 3.67 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 41 | 0 | 3 | 4 | 1.80 | .254 | 1.02 | 6.0 | 3.2 | 9.8 | 45.0 | 30 | 10 | 9 | 2 | 16 | 49 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.47 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 33 | 0 | 3 | 0 | 2.53 | .220 | 0.84 | 3.9 | 3.9 | 8.1 | 42.2 | 18 | 13 | 12 | 2 | 18 | 38 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.10 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 21 | 1 | 5 | 4 | 3.86 | .305 | 1.29 | 8.0 | 3.6 | 7.1 | 102.2 | 91 | 46 | 44 | 10 | 41 | 81 | 0 | 0 | 1 | 0 | 1 | 3 | 2 | 3.98 |