| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 24 | 24 | 6 | 12 | 3.90 | .299 | 1.26 | 8.1 | 3.2 | 8.2 | 161.1 | 145 | 76 | 70 | 22 | 58 | 146 | 0 | 0 | 0 | 0 | 15 | 3 | 4 | 4.10 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 23 | 23 | 4 | 13 | 4.03 | .305 | 1.30 | 9.7 | 2.1 | 5.1 | 158.2 | 170 | 78 | 71 | 16 | 37 | 89 | 2 | 0 | 0 | 0 | 13 | 2 | 3 | 3.93 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 22 | 22 | 6 | 7 | 5.19 | .312 | 1.35 | 9.8 | 2.4 | 5.7 | 149.0 | 162 | 88 | 86 | 25 | 39 | 95 | 4 | 0 | 0 | 0 | 10 | 2 | 4 | 4.73 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 22 | 22 | 10 | 9 | 3.90 | .308 | 1.32 | 9.2 | 2.6 | 6.5 | 150.0 | 154 | 72 | 65 | 13 | 44 | 108 | 5 | 0 | 0 | 2 | 11 | 2 | 3 | 3.61 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 22 | 22 | 9 | 10 | 4.94 | .331 | 1.44 | 10.2 | 2.8 | 4.1 | 142.0 | 161 | 83 | 78 | 22 | 44 | 65 | 3 | 0 | 0 | 0 | 11 | 6 | 10 | 5.15 |
| RP | Brewer, J.Brewer, Jim † >> | 35 | 1972 | L | 73 | 59 | 0 | 12 | 3 | 2.90 | .269 | 1.04 | 6.0 | 3.5 | 4.5 | 80.2 | 53 | 29 | 26 | 8 | 31 | 40 | 0 | 0 | 1 | 0 | 0 | 5 | 3 | 4.65 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 37 | 0 | 3 | 0 | 4.19 | .270 | 1.11 | 5.6 | 4.5 | 7.7 | 34.1 | 21 | 16 | 16 | 4 | 17 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 4.32 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 22 | 0 | 1 | 0 | 2.96 | .261 | 1.06 | 7.0 | 2.7 | 4.7 | 27.1 | 21 | 9 | 9 | 2 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.81 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 32 | 0 | 0 | 2 | 5.27 | .333 | 1.43 | 10.0 | 3.0 | 8.7 | 27.1 | 30 | 16 | 16 | 3 | 9 | 26 | 0 | 26 | 4 | 0 | 0 | 2 | 1 | 3.74 |
| SP | Carpenter, C.Carpenter, Chris >> | 30 | 2005 | R | 19 | 11 | 0 | 1 | 2 | 9.00 | .406 | 2.02 | 14.7 | 3.5 | 5.5 | 41.0 | 67 | 46 | 41 | 6 | 16 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.93 |