| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 27 | 27 | 8 | 11 | 4.44 | .313 | 1.33 | 9.1 | 2.9 | 9.1 | 188.2 | 191 | 102 | 93 | 29 | 60 | 191 | 7 | 0 | 0 | 2 | 14 | 7 | 3 | 4.04 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 26 | 26 | 11 | 8 | 3.57 | .272 | 1.10 | 7.4 | 2.5 | 5.7 | 194.1 | 160 | 78 | 77 | 24 | 53 | 122 | 8 | 0 | 0 | 2 | 16 | 5 | 1 | 4.25 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 25 | 25 | 12 | 9 | 4.29 | .313 | 1.36 | 8.8 | 3.4 | 8.3 | 170.0 | 167 | 87 | 81 | 24 | 64 | 156 | 2 | 0 | 0 | 0 | 14 | 1 | 2 | 4.15 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 25 | 25 | 12 | 4 | 4.93 | .329 | 1.46 | 10.1 | 3.1 | 5.8 | 169.2 | 190 | 99 | 93 | 19 | 58 | 109 | 1 | 0 | 0 | 0 | 12 | 2 | 4 | 4.24 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 56 | 0 | 7 | 0 | 3.41 | .297 | 1.27 | 7.5 | 4.0 | 9.0 | 68.2 | 57 | 27 | 26 | 7 | 30 | 68 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 3.66 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 40 | 0 | 4 | 3 | 2.38 | .209 | 0.77 | 4.9 | 2.0 | 8.8 | 53.0 | 29 | 15 | 14 | 6 | 12 | 52 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 3.25 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 36 | 0 | 4 | 4 | 3.96 | .266 | 1.09 | 8.8 | 1.2 | 9.2 | 38.2 | 37 | 18 | 17 | 4 | 5 | 39 | 0 | 5 | 2 | 0 | 0 | 0 | 2 | 2.71 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 25 | 0 | 1 | 1 | 7.43 | .378 | 1.83 | 10.2 | 6.3 | 10.6 | 23.0 | 26 | 20 | 19 | 5 | 16 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.57 |