| SP | deGrom, J.deGrom, Jacob † # >> | 33 | 2021 | R | 100 | 26 | 26 | 15 | 6 | 2.12 | .227 | 0.87 | 5.7 | 2.1 | 9.4 | 187.0 | 119 | 47 | 44 | 10 | 44 | 195 | 0 | 0 | 0 | 0 | 20 | 2 | 0 | 2.35 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 25 | 25 | 10 | 10 | 4.46 | .328 | 1.44 | 8.9 | 4.0 | 7.9 | 169.1 | 168 | 95 | 84 | 21 | 75 | 149 | 4 | 0 | 0 | 0 | 12 | 5 | 2 | 4.27 |
| SP | Sutton, D.Sutton, Don † >> | 27 | 1972 | R | 82 | 24 | 24 | 13 | 8 | 3.84 | .274 | 1.12 | 7.7 | 2.4 | 5.5 | 189.2 | 161 | 84 | 81 | 21 | 51 | 115 | 11 | 0 | 0 | 3 | 11 | 3 | 2 | 4.08 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 75 | 0 | 4 | 1 | 2.65 | .221 | 0.85 | 5.8 | 1.9 | 9.3 | 68.0 | 44 | 21 | 20 | 8 | 14 | 70 | 0 | 9 | 2 | 0 | 0 | 0 | 1 | 3.09 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 49 | 0 | 4 | 1 | 2.08 | .252 | 0.98 | 6.6 | 2.4 | 7.9 | 34.2 | 25 | 8 | 8 | 2 | 9 | 30 | 0 | 5 | 1 | 0 | 0 | 1 | 3 | 2.88 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 28 | 0 | 5 | 2 | 3.99 | .261 | 1.06 | 5.6 | 4.0 | 7.8 | 29.1 | 18 | 13 | 13 | 2 | 13 | 25 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.52 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 12 | 0 | 0 | 0 | 2.79 | .341 | 1.55 | 10.0 | 5.0 | 7.0 | 9.2 | 10 | 3 | 3 | 2 | 5 | 7 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 6.00 |