| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 19 | 19 | 7 | 6 | 3.46 | .271 | 1.09 | 7.5 | 2.4 | 8.8 | 132.2 | 110 | 52 | 51 | 14 | 35 | 129 | 0 | 0 | 0 | 0 | 14 | 3 | 0 | 3.29 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 77 | 18 | 18 | 10 | 8 | 3.67 | .277 | 1.14 | 6.9 | 3.5 | 5.8 | 122.2 | 93 | 55 | 50 | 14 | 47 | 78 | 3 | 0 | 0 | 0 | 11 | 1 | 3 | 4.39 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 17 | 17 | 6 | 7 | 3.74 | .312 | 1.34 | 8.6 | 3.5 | 4.9 | 122.2 | 116 | 62 | 51 | 12 | 48 | 66 | 2 | 0 | 0 | 0 | 9 | 3 | 2 | 4.45 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 18 | 6 | 5 | 4 | 4.05 | .309 | 1.33 | 8.2 | 3.9 | 4.0 | 86.2 | 78 | 46 | 39 | 11 | 37 | 38 | 1 | 1 | 0 | 0 | 2 | 1 | 3 | 5.10 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 46 | 0 | 1 | 0 | 2.67 | .254 | 1.02 | 5.7 | 3.6 | 7.2 | 30.1 | 19 | 11 | 9 | 3 | 12 | 24 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.90 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 22 | 0 | 1 | 1 | 3.21 | .364 | 1.71 | 7.7 | 7.7 | 8.4 | 14.0 | 12 | 7 | 5 | 1 | 12 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.64 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 38 | 0 | 2 | 5 | 4.35 | .213 | 0.81 | 4.8 | 2.5 | 6.7 | 39.1 | 21 | 19 | 19 | 4 | 11 | 29 | 0 | 23 | 3 | 0 | 0 | 0 | 0 | 3.69 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 14 | 11 | 2 | 5 | 7.63 | .372 | 1.76 | 12.4 | 3.6 | 9.4 | 63.2 | 87 | 56 | 54 | 12 | 25 | 66 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 4.62 |