| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 23 | 23 | 16 | 1 | 2.10 | .250 | 0.98 | 5.9 | 2.9 | 9.0 | 162.2 | 107 | 38 | 38 | 14 | 53 | 162 | 0 | 0 | 0 | 0 | 21 | 3 | 0 | 3.16 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 23 | 23 | 8 | 7 | 3.87 | .292 | 1.22 | 8.6 | 2.5 | 5.2 | 132.2 | 126 | 64 | 57 | 19 | 36 | 76 | 2 | 0 | 0 | 0 | 11 | 2 | 1 | 4.58 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 23 | 23 | 10 | 5 | 3.52 | .262 | 1.07 | 7.6 | 2.0 | 7.5 | 138.0 | 117 | 56 | 54 | 15 | 30 | 115 | 1 | 0 | 0 | 1 | 15 | 0 | 3 | 3.40 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 22 | 22 | 9 | 7 | 5.46 | .335 | 1.50 | 9.7 | 3.8 | 6.1 | 117.0 | 126 | 74 | 71 | 21 | 49 | 79 | 0 | 0 | 0 | 0 | 11 | 2 | 1 | 5.29 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 56 | 0 | 5 | 7 | 3.68 | .254 | 0.98 | 7.2 | 1.7 | 10.6 | 78.1 | 62 | 33 | 32 | 10 | 15 | 92 | 0 | 5 | 1 | 0 | 0 | 3 | 0 | 3.00 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 39 | 0 | 4 | 1 | 3.44 | .338 | 1.53 | 8.1 | 5.9 | 8.6 | 49.2 | 44 | 19 | 19 | 3 | 32 | 47 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.84 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 30 | 0 | 2 | 0 | 2.92 | .343 | 1.54 | 8.0 | 5.8 | 7.5 | 37.0 | 33 | 12 | 12 | 4 | 24 | 31 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.76 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 28 | 0 | 0 | 3 | 4.36 | .313 | 1.33 | 8.7 | 3.3 | 7.9 | 33.0 | 32 | 16 | 16 | 5 | 12 | 29 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 4.39 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 71 | 19 | 0 | 3 | 5 | 4.96 | .280 | 1.17 | 7.8 | 2.7 | 5.0 | 78.0 | 68 | 45 | 43 | 10 | 23 | 43 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 4.45 |