| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 17 | 17 | 5 | 3 | 4.40 | .316 | 1.36 | 8.0 | 4.2 | 8.3 | 90.0 | 80 | 44 | 44 | 11 | 42 | 83 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 4.24 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 17 | 17 | 5 | 10 | 4.95 | .272 | 1.10 | 7.8 | 2.1 | 5.7 | 100.0 | 87 | 55 | 55 | 15 | 23 | 63 | 1 | 0 | 0 | 0 | 8 | 2 | 1 | 4.44 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 17 | 17 | 3 | 4 | 4.19 | .306 | 1.31 | 9.3 | 2.5 | 7.2 | 92.1 | 95 | 45 | 43 | 13 | 26 | 74 | 0 | 0 | 0 | 0 | 12 | 1 | 0 | 4.11 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 17 | 17 | 8 | 6 | 4.05 | .262 | 1.05 | 7.4 | 2.0 | 4.7 | 120.0 | 99 | 60 | 54 | 16 | 27 | 62 | 1 | 0 | 0 | 0 | 8 | 2 | 3 | 4.43 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 45 | 0 | 3 | 3 | 3.11 | .268 | 1.08 | 7.6 | 2.3 | 6.4 | 63.2 | 53 | 24 | 22 | 4 | 16 | 45 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 3.21 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 40 | 0 | 4 | 3 | 2.38 | .234 | 0.88 | 6.4 | 1.6 | 8.2 | 56.2 | 40 | 15 | 15 | 9 | 10 | 51 | 0 | 6 | 2 | 0 | 0 | 2 | 0 | 3.91 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 17 | 0 | 3 | 0 | 2.95 | .225 | 0.82 | 3.0 | 4.5 | 8.0 | 18.1 | 6 | 6 | 6 | 0 | 9 | 16 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 2.89 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 7 | 0 | 0 | 0 | 1.08 | .342 | 1.56 | 9.0 | 5.6 | 9.0 | 8.1 | 8 | 1 | 1 | 0 | 5 | 8 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 2.88 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 11 | 0 | 1 | 0 | 1.29 | .236 | 0.93 | 3.9 | 4.5 | 6.4 | 14.0 | 6 | 5 | 2 | 1 | 7 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.00 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 13 | 0 | 0 | 0 | 4.44 | .336 | 1.48 | 8.6 | 4.9 | 5.6 | 24.1 | 23 | 14 | 12 | 3 | 13 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.13 |