| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 28 | 28 | 15 | 7 | 3.17 | .281 | 1.15 | 7.3 | 3.1 | 9.5 | 199.0 | 161 | 75 | 70 | 18 | 68 | 209 | 2 | 0 | 0 | 0 | 21 | 4 | 4 | 3.16 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 87 | 27 | 27 | 10 | 10 | 4.79 | .324 | 1.40 | 9.3 | 3.4 | 9.5 | 178.2 | 184 | 104 | 95 | 36 | 67 | 188 | 1 | 0 | 0 | 0 | 15 | 6 | 16 | 4.75 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 69 | 27 | 27 | 7 | 12 | 5.30 | .334 | 1.49 | 9.9 | 3.5 | 6.4 | 192.0 | 211 | 119 | 113 | 31 | 75 | 136 | 3 | 0 | 0 | 0 | 8 | 3 | 5 | 4.90 |
| SP | Harden, R.Harden, Rich † >> | 27 | 2008 | R | 68 | 25 | 25 | 16 | 5 | 3.51 | .316 | 1.38 | 7.9 | 4.5 | 8.7 | 156.1 | 137 | 61 | 61 | 18 | 78 | 150 | 0 | 0 | 0 | 0 | 16 | 2 | 1 | 4.12 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 72 | 0 | 5 | 2 | 3.59 | .271 | 1.07 | 5.2 | 4.6 | 9.7 | 87.2 | 50 | 36 | 35 | 8 | 44 | 94 | 0 | 3 | 3 | 0 | 0 | 4 | 1 | 3.69 |
| CL | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 91 | 53 | 0 | 4 | 7 | 3.54 | .300 | 1.27 | 7.9 | 3.5 | 9.3 | 56.0 | 49 | 25 | 22 | 8 | 22 | 58 | 0 | 32 | 4 | 0 | 0 | 1 | 0 | 4.02 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 57 | 0 | 4 | 4 | 2.69 | .277 | 1.13 | 6.6 | 3.7 | 10.0 | 63.2 | 46 | 22 | 19 | 7 | 26 | 70 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.51 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 35 | 0 | 3 | 2 | 5.84 | .319 | 1.41 | 11.2 | 1.5 | 10.0 | 37.0 | 46 | 29 | 24 | 9 | 6 | 41 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.43 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 9 | 1 | 0 | 0 | 5.54 | .374 | 1.69 | 12.6 | 2.7 | 7.1 | 37.1 | 52 | 27 | 23 | 5 | 11 | 29 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 4.41 |