| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 34 | 34 | 15 | 11 | 3.29 | .268 | 1.07 | 7.3 | 2.3 | 10.7 | 240.2 | 195 | 96 | 88 | 25 | 62 | 286 | 4 | 0 | 0 | 3 | 25 | 7 | 2 | 2.83 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 33 | 33 | 16 | 10 | 4.24 | .297 | 1.25 | 8.2 | 3.0 | 9.6 | 210.1 | 191 | 101 | 99 | 35 | 71 | 223 | 0 | 0 | 0 | 0 | 19 | 5 | 2 | 4.13 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 30 | 30 | 12 | 7 | 3.70 | .286 | 1.19 | 7.8 | 3.0 | 8.7 | 182.2 | 158 | 77 | 75 | 25 | 60 | 175 | 0 | 0 | 0 | 0 | 19 | 2 | 9 | 3.88 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 85 | 0 | 10 | 4 | 2.33 | .249 | 0.96 | 7.0 | 1.6 | 9.9 | 104.1 | 81 | 28 | 27 | 8 | 19 | 114 | 0 | 4 | 3 | 0 | 0 | 4 | 0 | 2.47 |
| RP | Chapman, A.Chapman, Aroldis >> | 24 | 2012 | L | 88 | 84 | 0 | 3 | 2 | 4.10 | .341 | 1.52 | 8.2 | 5.5 | 10.5 | 59.1 | 54 | 32 | 27 | 11 | 36 | 69 | 0 | 7 | 5 | 0 | 0 | 2 | 1 | 5.02 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 76 | 0 | 1 | 1 | 1.97 | .237 | 0.91 | 5.4 | 2.9 | 9.2 | 50.1 | 30 | 11 | 11 | 5 | 16 | 51 | 0 | 17 | 2 | 0 | 0 | 1 | 0 | 3.28 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 20 | 0 | 5 | 1 | 4.15 | .339 | 1.38 | 7.6 | 4.8 | 9.7 | 13.0 | 11 | 6 | 6 | 3 | 7 | 14 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 5.92 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 50 | 0 | 2 | 1 | 3.86 | .340 | 1.54 | 9.4 | 4.7 | 10.2 | 23.1 | 24 | 11 | 10 | 2 | 12 | 26 | 0 | 8 | 0 | 0 | 0 | 0 | 4 | 3.43 |