| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 28 | 28 | 13 | 5 | 2.93 | .262 | 1.03 | 6.7 | 2.6 | 11.1 | 181.1 | 134 | 60 | 59 | 21 | 53 | 224 | 1 | 0 | 0 | 0 | 21 | 6 | 2 | 3.01 |
| SP | Schwellenbach, S.Schwellenbach, Spencer † >> | 25 | 2025 | R | 86 | 27 | 27 | 14 | 8 | 3.78 | .284 | 1.16 | 8.2 | 2.3 | 8.2 | 188.0 | 171 | 84 | 79 | 25 | 48 | 171 | 1 | 0 | 0 | 0 | 17 | 5 | 4 | 3.76 |
| SP | Abbott, A.Abbott, Andrew # >> | 26 | 2025 | L | 67 | 26 | 26 | 10 | 11 | 5.85 | .349 | 1.57 | 10.9 | 3.3 | 5.8 | 150.2 | 181 | 104 | 98 | 20 | 55 | 97 | 0 | 0 | 0 | 0 | 10 | 6 | 3 | 4.66 |
| CL | Miller, M.Miller, Mason † >> | 26 | 2025 | R | 98 | 57 | 0 | 2 | 5 | 3.17 | .314 | 1.33 | 6.8 | 5.2 | 12.3 | 54.0 | 41 | 19 | 19 | 3 | 31 | 74 | 0 | 39 | 4 | 0 | 0 | 2 | 0 | 2.81 |
| SU | Iglesias, R.Iglesias, Raisel >> | 35 | 2025 | R | 80 | 58 | 0 | 0 | 6 | 5.05 | .353 | 1.62 | 11.3 | 3.3 | 11.8 | 62.1 | 78 | 35 | 35 | 8 | 23 | 81 | 0 | 3 | 6 | 0 | 0 | 1 | 0 | 3.23 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 71 | 0 | 4 | 1 | 4.70 | .338 | 1.53 | 9.2 | 4.8 | 10.8 | 51.2 | 52 | 28 | 27 | 4 | 27 | 61 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.22 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 75 | 0 | 2 | 1 | 2.48 | .256 | 0.99 | 6.0 | 3.0 | 9.3 | 54.1 | 36 | 16 | 15 | 5 | 18 | 56 | 0 | 3 | 0 | 0 | 0 | 2 | 1 | 3.24 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 71 | 32 | 0 | 2 | 0 | 3.66 | .324 | 1.44 | 8.4 | 4.5 | 7.6 | 32.0 | 30 | 13 | 13 | 4 | 16 | 27 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.44 |
| SP | Suarez, R.Suarez, Ranger >> | 29 | 2025 | L | 51 | 18 | 0 | 3 | 0 | 5.22 | .328 | 1.45 | 10.1 | 3.1 | 9.8 | 58.2 | 65 | 34 | 34 | 8 | 20 | 63 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.71 |