| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 36 | 36 | 15 | 9 | 2.70 | .280 | 1.13 | 7.8 | 2.5 | 10.8 | 249.2 | 215 | 75 | 75 | 15 | 68 | 298 | 0 | 0 | 0 | 0 | 29 | 9 | 5 | 2.32 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 33 | 33 | 15 | 11 | 4.80 | .313 | 1.32 | 9.4 | 2.5 | 10.5 | 197.0 | 206 | 110 | 105 | 36 | 55 | 229 | 0 | 0 | 0 | 0 | 19 | 8 | 7 | 4.01 |
| SP | Singer, B.Singer, Brady >> | 28 | 2025 | R | 60 | 33 | 33 | 11 | 14 | 5.67 | .347 | 1.56 | 9.9 | 4.1 | 7.3 | 168.1 | 185 | 111 | 106 | 20 | 77 | 136 | 0 | 0 | 0 | 0 | 8 | 6 | 3 | 4.41 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 57 | 32 | 31 | 8 | 12 | 5.17 | .335 | 1.46 | 9.6 | 3.5 | 7.0 | 155.0 | 166 | 89 | 89 | 22 | 61 | 120 | 0 | 0 | 0 | 0 | 9 | 7 | 4 | 4.61 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 81 | 0 | 3 | 8 | 3.36 | .301 | 1.27 | 7.5 | 3.9 | 11.1 | 80.1 | 67 | 30 | 30 | 8 | 35 | 99 | 0 | 42 | 1 | 0 | 0 | 2 | 6 | 3.21 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 81 | 0 | 8 | 3 | 4.30 | .334 | 1.46 | 9.1 | 4.1 | 10.6 | 81.2 | 82 | 40 | 39 | 8 | 37 | 95 | 0 | 2 | 4 | 0 | 0 | 4 | 0 | 3.46 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 104 | 0 | 4 | 3 | 3.22 | .286 | 1.16 | 6.6 | 3.9 | 8.8 | 114.2 | 83 | 41 | 41 | 5 | 50 | 111 | 0 | 0 | 1 | 0 | 0 | 5 | 5 | 3.07 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 31 | 2025 | R | 74 | 95 | 0 | 6 | 3 | 4.19 | .312 | 1.34 | 8.2 | 3.9 | 8.3 | 107.1 | 98 | 52 | 50 | 18 | 46 | 99 | 0 | 0 | 3 | 0 | 0 | 2 | 1 | 4.68 |
| RP | Finnegan, K.Finnegan, Kyle >> | 33 | 2025 | R | 64 | 79 | 0 | 3 | 1 | 5.15 | .366 | 1.71 | 10.2 | 5.2 | 6.9 | 80.1 | 91 | 46 | 46 | 9 | 46 | 61 | 0 | 4 | 5 | 0 | 0 | 2 | 5 | 4.74 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 66 | 0 | 4 | 0 | 2.25 | .294 | 1.18 | 6.0 | 4.6 | 7.0 | 76.0 | 51 | 19 | 19 | 2 | 39 | 59 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 3.53 |