| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 26 | 26 | 10 | 11 | 4.02 | .299 | 1.25 | 8.4 | 2.9 | 8.9 | 183.2 | 171 | 82 | 82 | 21 | 59 | 180 | 6 | 0 | 0 | 2 | 15 | 5 | 2 | 3.57 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 26 | 26 | 6 | 15 | 5.59 | .344 | 1.56 | 11.0 | 3.1 | 9.4 | 170.2 | 207 | 108 | 106 | 22 | 59 | 177 | 0 | 0 | 0 | 0 | 9 | 3 | 4 | 3.69 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 25 | 25 | 12 | 6 | 4.95 | .309 | 1.30 | 9.2 | 2.5 | 5.8 | 167.1 | 171 | 96 | 92 | 26 | 47 | 107 | 2 | 0 | 0 | 0 | 13 | 7 | 5 | 4.71 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 53 | 0 | 7 | 7 | 2.93 | .300 | 1.27 | 9.0 | 2.5 | 9.3 | 55.1 | 55 | 20 | 18 | 2 | 15 | 57 | 0 | 22 | 1 | 0 | 0 | 1 | 2 | 2.27 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 64 | 0 | 7 | 1 | 3.49 | .316 | 1.37 | 8.2 | 4.2 | 9.3 | 67.0 | 61 | 29 | 26 | 7 | 31 | 69 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.73 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 47 | 0 | 5 | 2 | 3.94 | .296 | 1.26 | 7.5 | 4.0 | 6.1 | 59.1 | 49 | 29 | 26 | 4 | 26 | 40 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.85 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 31 | 0 | 1 | 1 | 5.18 | .314 | 1.38 | 9.9 | 2.5 | 7.7 | 40.0 | 44 | 23 | 23 | 7 | 11 | 34 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.40 |
| SU | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 49 | 0 | 0 | 4 | 4.31 | .312 | 1.36 | 8.7 | 3.7 | 8.0 | 54.1 | 52 | 27 | 26 | 5 | 22 | 48 | 0 | 6 | 9 | 0 | 0 | 0 | 0 | 3.65 |