| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 16 | 16 | 4 | 7 | 4.42 | .293 | 1.24 | 6.8 | 4.5 | 8.6 | 95.2 | 72 | 48 | 47 | 9 | 47 | 91 | 0 | 0 | 0 | 0 | 10 | 0 | 3 | 3.80 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 16 | 16 | 10 | 3 | 2.86 | .286 | 1.17 | 8.6 | 2.0 | 5.2 | 110.0 | 105 | 37 | 35 | 5 | 24 | 63 | 1 | 0 | 0 | 1 | 11 | 3 | 3 | 3.18 |
| SP | Hughes, T.Hughes, Tom # >> | 31 | 1915 | R | 63 | 16 | 16 | 2 | 5 | 4.46 | .328 | 1.43 | 10.1 | 2.9 | 5.9 | 84.2 | 94 | 46 | 42 | 5 | 27 | 55 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 3.54 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 16 | 16 | 6 | 6 | 3.59 | .311 | 1.33 | 9.1 | 2.9 | 5.0 | 107.2 | 108 | 52 | 43 | 10 | 35 | 59 | 6 | 0 | 0 | 2 | 10 | 3 | 3 | 4.18 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 15 | 15 | 7 | 6 | 3.75 | .303 | 1.28 | 7.1 | 4.5 | 7.4 | 100.2 | 79 | 43 | 42 | 12 | 50 | 82 | 1 | 0 | 0 | 0 | 10 | 2 | 1 | 4.48 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 42 | 0 | 5 | 2 | 1.93 | .282 | 1.16 | 5.3 | 5.1 | 9.6 | 56.0 | 33 | 12 | 12 | 2 | 32 | 60 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.09 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 43 | 0 | 2 | 4 | 4.50 | .315 | 1.30 | 7.6 | 4.1 | 6.3 | 50.0 | 42 | 26 | 25 | 4 | 23 | 35 | 0 | 11 | 2 | 0 | 0 | 4 | 0 | 4.26 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 28 | 0 | 1 | 3 | 4.70 | .330 | 1.46 | 7.4 | 5.7 | 5.1 | 46.0 | 38 | 25 | 24 | 5 | 29 | 26 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 5.24 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 24 | 0 | 1 | 2 | 2.55 | .230 | 0.90 | 4.9 | 3.2 | 7.9 | 42.1 | 23 | 12 | 12 | 4 | 15 | 37 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.55 |
| SP | Vaughn, H.Vaughn, Hippo >> | 30 | 1918 | L | 40 | 11 | 0 | 0 | 3 | 5.79 | .364 | 1.71 | 12.1 | 3.5 | 5.5 | 23.1 | 31 | 17 | 15 | 3 | 9 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.65 |