| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 22 | 22 | 2 | 9 | 5.52 | .343 | 1.53 | 9.7 | 4.1 | 8.3 | 106.0 | 114 | 69 | 65 | 20 | 48 | 98 | 1 | 0 | 0 | 1 | 6 | 4 | 3 | 5.08 |
| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 22 | 22 | 6 | 9 | 5.41 | .304 | 1.30 | 9.2 | 2.5 | 8.8 | 123.0 | 126 | 78 | 74 | 22 | 34 | 120 | 0 | 0 | 0 | 0 | 10 | 1 | 3 | 4.23 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 21 | 21 | 6 | 7 | 5.20 | .312 | 1.36 | 10.0 | 2.3 | 5.2 | 98.2 | 109 | 60 | 57 | 16 | 25 | 57 | 0 | 0 | 0 | 0 | 9 | 0 | 1 | 4.72 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 54 | 0 | 4 | 5 | 5.56 | .326 | 1.41 | 8.6 | 4.2 | 8.3 | 69.2 | 66 | 44 | 43 | 10 | 32 | 64 | 0 | 0 | 4 | 0 | 0 | 3 | 0 | 4.55 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 45 | 0 | 0 | 2 | 4.14 | .287 | 1.21 | 6.4 | 4.7 | 8.8 | 58.2 | 41 | 31 | 27 | 6 | 30 | 57 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.93 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 47 | 0 | 3 | 1 | 3.41 | .307 | 1.29 | 8.4 | 3.3 | 9.0 | 58.0 | 54 | 23 | 22 | 4 | 21 | 58 | 0 | 0 | 2 | 0 | 0 | 2 | 4 | 3.09 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 46 | 0 | 0 | 4 | 3.54 | .279 | 1.13 | 6.1 | 4.1 | 9.5 | 53.1 | 36 | 22 | 21 | 5 | 24 | 56 | 0 | 2 | 3 | 0 | 0 | 2 | 2 | 3.58 |
| SP | McQuillan, G.McQuillan, George >> | 23 | 1908 | R | 48 | 15 | 0 | 3 | 1 | 2.95 | .295 | 1.20 | 7.3 | 3.8 | 3.0 | 36.2 | 29 | 14 | 12 | 2 | 15 | 12 | 0 | 3 | 0 | 0 | 0 | 2 | 1 | 4.47 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 47 | 0 | 3 | 1 | 3.29 | .288 | 1.15 | 5.5 | 4.8 | 8.8 | 52.0 | 32 | 19 | 19 | 6 | 28 | 51 | 0 | 25 | 5 | 0 | 0 | 3 | 1 | 4.33 |