| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 24 | 24 | 10 | 8 | 3.28 | .250 | 0.97 | 6.0 | 2.7 | 4.7 | 164.2 | 110 | 64 | 60 | 8 | 50 | 85 | 3 | 0 | 0 | 1 | 15 | 5 | 5 | 3.60 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 23 | 23 | 9 | 6 | 4.47 | .297 | 1.25 | 9.0 | 2.3 | 7.6 | 139.0 | 139 | 73 | 69 | 19 | 35 | 118 | 0 | 0 | 0 | 0 | 13 | 2 | 1 | 3.88 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 23 | 23 | 7 | 10 | 5.06 | .315 | 1.36 | 10.0 | 2.3 | 8.0 | 131.2 | 146 | 78 | 74 | 17 | 33 | 116 | 1 | 0 | 0 | 0 | 11 | 3 | 2 | 3.74 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 7 | 7 | 3 | 2 | 7.00 | .368 | 1.64 | 10.0 | 4.8 | 4.0 | 36.0 | 40 | 29 | 28 | 6 | 19 | 16 | 0 | 0 | 0 | 0 | 1 | 4 | 2 | 6.19 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 59 | 0 | 0 | 1 | 3.30 | .307 | 1.29 | 6.9 | 4.7 | 7.5 | 79.0 | 61 | 33 | 29 | 6 | 41 | 66 | 0 | 2 | 2 | 0 | 0 | 3 | 2 | 3.99 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 36 | 0 | 4 | 0 | 3.08 | .317 | 1.39 | 7.3 | 5.2 | 8.8 | 38.0 | 31 | 15 | 13 | 4 | 22 | 37 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.16 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 26 | 0 | 1 | 0 | 2.93 | .291 | 1.16 | 6.7 | 4.0 | 7.7 | 27.2 | 20 | 9 | 9 | 3 | 12 | 23 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.30 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 37 | 0 | 7 | 0 | 4.70 | .335 | 1.51 | 10.7 | 3.1 | 6.9 | 38.1 | 45 | 20 | 20 | 12 | 13 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.61 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 40 | 0 | 6 | 1 | 1.68 | .212 | 0.81 | 4.5 | 2.8 | 8.6 | 48.1 | 24 | 9 | 9 | 3 | 15 | 46 | 0 | 24 | 3 | 0 | 0 | 0 | 2 | 2.83 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 23 | 0 | 4 | 0 | 2.41 | .285 | 1.18 | 6.6 | 4.0 | 5.1 | 56.0 | 41 | 15 | 15 | 3 | 25 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 3.95 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 43 | 0 | 3 | 2 | 3.53 | .311 | 1.35 | 6.9 | 5.3 | 7.6 | 51.0 | 39 | 23 | 20 | 5 | 30 | 43 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 4.35 |