| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 26 | 26 | 13 | 7 | 2.73 | .261 | 1.04 | 7.2 | 2.2 | 8.2 | 178.0 | 142 | 56 | 54 | 10 | 44 | 163 | 1 | 0 | 0 | 1 | 18 | 3 | 3 | 2.69 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 25 | 25 | 13 | 5 | 3.74 | .299 | 1.25 | 8.5 | 2.7 | 4.3 | 178.0 | 169 | 80 | 74 | 12 | 54 | 86 | 4 | 0 | 0 | 1 | 15 | 5 | 2 | 3.90 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 82 | 25 | 25 | 16 | 5 | 3.27 | .261 | 1.06 | 6.3 | 3.2 | 8.4 | 157.0 | 110 | 58 | 57 | 15 | 56 | 146 | 0 | 0 | 0 | 0 | 17 | 0 | 9 | 3.45 |
| SP | Pfiester, J.Pfiester, Jack † >> | 28 | 1906 | L | 73 | 24 | 24 | 13 | 10 | 3.72 | .301 | 1.29 | 8.1 | 3.5 | 5.0 | 169.1 | 153 | 78 | 70 | 10 | 65 | 93 | 8 | 0 | 0 | 1 | 15 | 1 | 3 | 3.84 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 23 | 23 | 9 | 9 | 3.99 | .308 | 1.30 | 8.6 | 3.1 | 4.7 | 149.0 | 142 | 78 | 66 | 13 | 52 | 78 | 2 | 0 | 0 | 1 | 13 | 5 | 3 | 4.23 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 51 | 0 | 2 | 6 | 3.42 | .276 | 1.04 | 5.0 | 4.4 | 6.9 | 47.1 | 26 | 20 | 18 | 4 | 23 | 36 | 0 | 38 | 4 | 0 | 0 | 5 | 0 | 4.36 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 41 | 0 | 0 | 0 | 2.06 | .238 | 0.92 | 4.8 | 3.6 | 6.7 | 43.2 | 23 | 12 | 10 | 4 | 17 | 32 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.98 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 57 | 0 | 6 | 4 | 3.62 | .269 | 1.06 | 6.6 | 3.1 | 8.4 | 59.2 | 43 | 25 | 24 | 7 | 20 | 55 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 3.85 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 27 | 0 | 1 | 0 | 3.30 | .297 | 1.27 | 9.6 | 1.8 | 7.2 | 30.0 | 32 | 15 | 11 | 3 | 6 | 24 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.30 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 51 | 8 | 0 | 1 | 1 | 1.00 | .129 | 0.44 | 4.0 | 0.0 | 11.0 | 9.0 | 4 | 1 | 1 | 0 | 0 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.56 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 10 | 0 | 0 | 0 | 0.84 | .273 | 1.13 | 5.4 | 5.4 | 7.2 | 10.2 | 6 | 1 | 1 | 0 | 6 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.20 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 17 | 0 | 1 | 0 | 3.55 | .321 | 1.42 | 9.0 | 4.0 | 6.5 | 25.1 | 25 | 12 | 10 | 3 | 11 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.44 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 19 | 0 | 0 | 0 | 5.74 | .338 | 1.53 | 12.6 | 1.8 | 10.8 | 15.2 | 21 | 11 | 10 | 3 | 3 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.80 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 50 | 3 | 0 | 0 | 0 | 5.27 | .317 | 1.39 | 12.5 | 0.7 | 8.3 | 13.2 | 18 | 8 | 8 | 0 | 1 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.38 |