| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 26 | 26 | 6 | 9 | 4.21 | .318 | 1.36 | 9.4 | 2.9 | 7.8 | 147.1 | 154 | 82 | 69 | 20 | 47 | 128 | 1 | 0 | 0 | 0 | 14 | 5 | 3 | 4.09 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 26 | 26 | 11 | 7 | 3.30 | .269 | 1.09 | 7.9 | 1.9 | 5.0 | 169.0 | 148 | 73 | 62 | 12 | 36 | 93 | 5 | 0 | 0 | 3 | 13 | 3 | 2 | 3.51 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 22 | 22 | 8 | 10 | 4.56 | .305 | 1.31 | 8.7 | 3.1 | 9.4 | 116.1 | 112 | 59 | 59 | 21 | 40 | 121 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 4.33 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 66 | 0 | 7 | 2 | 3.23 | .289 | 1.21 | 6.7 | 4.2 | 10.4 | 92.0 | 68 | 34 | 33 | 6 | 43 | 106 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 2.98 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 67 | 0 | 1 | 5 | 3.25 | .282 | 1.18 | 7.3 | 3.4 | 10.2 | 83.0 | 67 | 35 | 30 | 6 | 31 | 94 | 0 | 8 | 3 | 0 | 0 | 0 | 2 | 2.80 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 53 | 0 | 3 | 5 | 2.83 | .232 | 0.90 | 6.4 | 1.8 | 8.5 | 76.1 | 54 | 24 | 24 | 4 | 15 | 72 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 2.38 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 46 | 0 | 5 | 4 | 4.58 | .310 | 1.31 | 8.2 | 3.6 | 6.7 | 55.0 | 50 | 31 | 28 | 2 | 22 | 41 | 0 | 3 | 2 | 0 | 0 | 2 | 4 | 3.29 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 12 | 1 | 2 | 2 | 4.98 | .335 | 1.46 | 9.5 | 3.7 | 7.4 | 34.1 | 36 | 19 | 19 | 6 | 14 | 28 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.06 |