| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 18 | 18 | 8 | 8 | 3.45 | .284 | 1.17 | 8.0 | 2.6 | 7.9 | 122.2 | 109 | 52 | 47 | 9 | 35 | 107 | 1 | 0 | 0 | 0 | 10 | 2 | 4 | 3.11 |
| SP | Alexander, P.Alexander, Pete † >> | 28 | 1915 | R | 88 | 18 | 18 | 10 | 6 | 2.62 | .268 | 1.09 | 7.7 | 2.2 | 4.7 | 137.2 | 117 | 41 | 40 | 10 | 33 | 71 | 4 | 0 | 0 | 1 | 12 | 1 | 2 | 3.66 |
| RP | Benitez, A.Benitez, Armando † >> | 32 | 2004 | R | 82 | 44 | 0 | 3 | 0 | 2.57 | .270 | 1.07 | 5.9 | 3.7 | 3.2 | 56.0 | 37 | 16 | 16 | 2 | 23 | 20 | 0 | 4 | 0 | 0 | 0 | 2 | 0 | 4.09 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 28 | 0 | 2 | 2 | 5.23 | .331 | 1.48 | 7.8 | 5.5 | 9.6 | 31.0 | 27 | 18 | 18 | 4 | 19 | 33 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.39 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 19 | 0 | 3 | 1 | 3.38 | .333 | 1.50 | 9.0 | 4.7 | 6.9 | 21.1 | 21 | 8 | 8 | 3 | 11 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.90 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 8 | 0 | 1 | 0 | 1.13 | .294 | 1.13 | 5.6 | 4.5 | 11.3 | 8.0 | 5 | 1 | 1 | 0 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.38 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 37 | 0 | 3 | 4 | 2.48 | .292 | 1.24 | 7.3 | 4.0 | 6.0 | 36.1 | 29 | 11 | 10 | 2 | 16 | 24 | 0 | 27 | 2 | 0 | 0 | 0 | 1 | 3.72 |