| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 26 | 26 | 10 | 10 | 3.72 | .288 | 1.19 | 8.7 | 2.0 | 4.6 | 179.0 | 173 | 82 | 74 | 18 | 40 | 91 | 3 | 0 | 0 | 2 | 17 | 4 | 4 | 4.03 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 25 | 25 | 10 | 8 | 4.58 | .313 | 1.32 | 8.4 | 3.4 | 7.1 | 157.1 | 147 | 86 | 80 | 16 | 60 | 123 | 1 | 0 | 0 | 1 | 13 | 8 | 4 | 4.06 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 22 | 22 | 7 | 10 | 5.23 | .321 | 1.38 | 9.4 | 3.0 | 6.4 | 141.0 | 148 | 84 | 82 | 16 | 47 | 101 | 1 | 0 | 0 | 1 | 9 | 5 | 1 | 4.15 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 23 | 23 | 14 | 7 | 3.54 | .282 | 1.18 | 8.0 | 2.6 | 9.5 | 145.0 | 129 | 59 | 57 | 13 | 42 | 153 | 3 | 0 | 0 | 2 | 16 | 0 | 3 | 2.92 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 48 | 0 | 5 | 7 | 3.97 | .296 | 1.26 | 6.9 | 4.6 | 10.1 | 47.2 | 36 | 26 | 21 | 4 | 24 | 53 | 0 | 23 | 4 | 0 | 0 | 0 | 1 | 3.38 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 48 | 0 | 0 | 0 | 2.16 | .286 | 1.18 | 6.1 | 4.5 | 9.7 | 50.0 | 34 | 12 | 12 | 1 | 25 | 54 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 2.66 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 59 | 0 | 4 | 2 | 4.20 | .320 | 1.38 | 8.9 | 3.7 | 8.3 | 64.1 | 63 | 32 | 30 | 8 | 26 | 59 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 4.09 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 28 | 0 | 0 | 0 | 3.25 | .291 | 1.23 | 5.0 | 6.3 | 9.3 | 27.2 | 15 | 10 | 10 | 1 | 19 | 28 | 0 | 2 | 1 | 0 | 0 | 0 | 4 | 3.52 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 36 | 0 | 0 | 2 | 4.14 | .319 | 1.35 | 10.1 | 2.2 | 7.9 | 41.1 | 46 | 21 | 19 | 7 | 10 | 36 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 4.34 |