| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 19 | 19 | 9 | 7 | 3.05 | .234 | 0.89 | 5.8 | 2.3 | 5.1 | 129.2 | 83 | 51 | 44 | 12 | 33 | 73 | 2 | 0 | 0 | 1 | 14 | 3 | 0 | 3.91 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 18 | 18 | 8 | 2 | 3.25 | .283 | 1.15 | 6.9 | 3.4 | 7.8 | 127.1 | 98 | 47 | 46 | 11 | 48 | 110 | 2 | 0 | 0 | 0 | 12 | 5 | 2 | 3.65 |
| SP | Fernandez, S.Fernandez, Sid † >> | 23 | 1985 | L | 49 | 18 | 18 | 11 | 2 | 2.45 | .235 | 0.90 | 5.7 | 2.4 | 7.5 | 125.0 | 79 | 35 | 34 | 14 | 33 | 104 | 4 | 0 | 0 | 2 | 14 | 3 | 2 | 3.66 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 18 | 18 | 5 | 5 | 4.49 | .322 | 1.38 | 10.3 | 2.2 | 4.3 | 108.1 | 124 | 61 | 54 | 12 | 26 | 52 | 3 | 0 | 0 | 0 | 9 | 4 | 1 | 4.31 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 18 | 18 | 8 | 10 | 3.70 | .295 | 1.24 | 7.5 | 3.6 | 4.7 | 129.0 | 108 | 56 | 53 | 16 | 52 | 67 | 5 | 0 | 0 | 2 | 10 | 2 | 4 | 4.83 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 48 | 0 | 6 | 0 | 1.92 | .250 | 0.99 | 4.6 | 4.3 | 9.2 | 75.0 | 38 | 16 | 16 | 7 | 36 | 77 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 3.64 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 32 | 0 | 2 | 2 | 3.60 | .277 | 1.15 | 8.3 | 2.0 | 9.7 | 40.0 | 37 | 16 | 16 | 3 | 9 | 43 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 24 | 0 | 6 | 1 | 3.30 | .280 | 1.13 | 5.1 | 5.1 | 5.4 | 30.0 | 17 | 11 | 11 | 5 | 17 | 18 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 5.77 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 23 | 0 | 2 | 2 | 7.48 | .393 | 1.89 | 12.9 | 4.7 | 5.1 | 21.2 | 30 | 19 | 18 | 4 | 11 | 12 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 6.05 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 16 | 0 | 2 | 0 | 0.46 | .203 | 0.76 | 5.7 | 1.4 | 9.5 | 19.2 | 12 | 2 | 1 | 0 | 3 | 20 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1.37 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 14 | 0 | 0 | 1 | 2.41 | .233 | 0.91 | 8.5 | 0.0 | 9.0 | 18.2 | 17 | 5 | 5 | 2 | 0 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.44 |