| SP | Tiant, L.Tiant, Luis † # >> | 28 | 1968 | R | 97 | 25 | 25 | 13 | 8 | 3.55 | .273 | 1.10 | 7.0 | 2.9 | 7.8 | 177.2 | 138 | 76 | 70 | 19 | 58 | 153 | 6 | 0 | 0 | 3 | 15 | 4 | 2 | 3.72 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 25 | 25 | 7 | 11 | 4.26 | .303 | 1.29 | 9.5 | 2.1 | 5.1 | 171.0 | 180 | 83 | 81 | 20 | 40 | 97 | 1 | 0 | 0 | 0 | 15 | 3 | 4 | 4.14 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 24 | 24 | 9 | 10 | 4.20 | .307 | 1.30 | 8.3 | 3.4 | 5.3 | 162.2 | 149 | 78 | 76 | 12 | 62 | 95 | 3 | 0 | 0 | 1 | 14 | 5 | 1 | 4.03 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 22 | 22 | 8 | 11 | 4.43 | .310 | 1.31 | 8.6 | 3.2 | 5.6 | 154.1 | 148 | 87 | 76 | 17 | 54 | 95 | 9 | 0 | 0 | 1 | 10 | 6 | 4 | 4.37 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 25 | 23 | 5 | 10 | 5.52 | .341 | 1.54 | 10.7 | 3.2 | 5.1 | 151.2 | 180 | 104 | 93 | 25 | 53 | 85 | 2 | 0 | 0 | 0 | 10 | 2 | 4 | 5.12 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 98 | 63 | 0 | 3 | 3 | 3.42 | .283 | 1.17 | 6.0 | 4.6 | 8.5 | 71.0 | 47 | 29 | 27 | 8 | 36 | 67 | 0 | 6 | 3 | 0 | 0 | 1 | 0 | 4.14 |
| RP | Pagan, E.Pagan, Emilio # >> | 28 | 2019 | R | 77 | 56 | 0 | 3 | 5 | 4.98 | .322 | 1.41 | 9.6 | 3.2 | 9.0 | 59.2 | 63 | 33 | 33 | 4 | 21 | 59 | 0 | 7 | 4 | 0 | 0 | 1 | 4 | 3.00 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 39 | 0 | 3 | 2 | 5.48 | .311 | 1.35 | 9.2 | 3.1 | 10.4 | 44.1 | 45 | 27 | 27 | 9 | 15 | 51 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 4.36 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 36 | 0 | 4 | 2 | 3.51 | .335 | 1.46 | 7.0 | 6.1 | 5.8 | 59.0 | 46 | 25 | 23 | 6 | 40 | 38 | 0 | 5 | 3 | 0 | 0 | 3 | 1 | 5.22 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 24 | 0 | 2 | 0 | 2.03 | .321 | 1.39 | 10.5 | 2.0 | 6.4 | 31.0 | 36 | 8 | 7 | 0 | 7 | 22 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.35 |