| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 28 | 28 | 11 | 14 | 4.87 | .312 | 1.31 | 8.6 | 3.2 | 7.4 | 203.1 | 194 | 114 | 110 | 23 | 73 | 167 | 9 | 0 | 0 | 0 | 11 | 9 | 6 | 4.04 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 28 | 28 | 9 | 11 | 5.22 | .349 | 1.59 | 10.9 | 3.4 | 7.8 | 170.2 | 206 | 102 | 99 | 30 | 65 | 148 | 0 | 0 | 0 | 0 | 12 | 3 | 6 | 4.75 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 27 | 27 | 15 | 7 | 5.04 | .317 | 1.38 | 9.5 | 3.0 | 4.2 | 182.0 | 192 | 104 | 102 | 25 | 60 | 84 | 5 | 0 | 0 | 1 | 12 | 1 | 1 | 4.87 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 27 | 27 | 12 | 10 | 4.46 | .320 | 1.36 | 9.5 | 2.8 | 5.3 | 185.2 | 195 | 101 | 92 | 22 | 57 | 108 | 5 | 0 | 0 | 0 | 14 | 10 | 7 | 4.46 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 26 | 26 | 6 | 8 | 6.83 | .373 | 1.74 | 10.2 | 5.6 | 7.5 | 114.2 | 129 | 88 | 87 | 18 | 71 | 95 | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 5.39 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 70 | 0 | 8 | 2 | 2.86 | .255 | 1.03 | 6.3 | 3.0 | 10.3 | 94.1 | 66 | 31 | 30 | 4 | 31 | 108 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 2.24 |
| RP | Gordon, T.Gordon, Tom † >> | 37 | 2004 | R | 62 | 57 | 0 | 4 | 2 | 3.41 | .284 | 1.17 | 7.3 | 3.3 | 8.1 | 58.0 | 47 | 23 | 22 | 6 | 21 | 52 | 0 | 9 | 1 | 0 | 0 | 1 | 1 | 3.69 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 56 | 30 | 0 | 3 | 5 | 3.58 | .329 | 1.47 | 7.6 | 5.8 | 2.9 | 50.1 | 42 | 21 | 20 | 3 | 32 | 16 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 5.06 |