| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 19 | 19 | 8 | 5 | 3.30 | .285 | 1.14 | 7.6 | 2.7 | 8.5 | 136.1 | 115 | 55 | 50 | 18 | 41 | 128 | 3 | 0 | 0 | 0 | 13 | 7 | 0 | 3.90 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 18 | 18 | 6 | 7 | 4.45 | .333 | 1.49 | 8.5 | 4.9 | 7.5 | 111.1 | 105 | 60 | 55 | 10 | 61 | 92 | 2 | 0 | 0 | 0 | 11 | 1 | 3 | 4.19 |
| SP | Brown, M.Brown, Mordecai # >> | 32 | 1908 | R | 85 | 18 | 18 | 6 | 9 | 3.54 | .267 | 1.06 | 7.3 | 2.3 | 4.5 | 129.2 | 105 | 55 | 51 | 11 | 33 | 65 | 6 | 0 | 0 | 1 | 12 | 4 | 3 | 3.96 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 18 | 18 | 5 | 5 | 4.65 | .341 | 1.53 | 10.1 | 3.8 | 5.0 | 98.2 | 110 | 57 | 51 | 8 | 41 | 54 | 0 | 0 | 0 | 0 | 10 | 2 | 0 | 4.28 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 47 | 0 | 1 | 6 | 4.79 | .299 | 1.24 | 8.0 | 3.2 | 7.4 | 56.1 | 50 | 30 | 30 | 11 | 20 | 46 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 5.09 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 44 | 0 | 2 | 5 | 4.12 | .306 | 1.32 | 9.5 | 2.4 | 8.1 | 59.0 | 62 | 27 | 27 | 8 | 16 | 53 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 3.78 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 67 | 35 | 0 | 2 | 3 | 2.90 | .313 | 1.31 | 8.6 | 3.4 | 9.2 | 40.1 | 38 | 13 | 13 | 6 | 15 | 41 | 0 | 4 | 0 | 0 | 0 | 2 | 3 | 4.18 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 31 | 0 | 2 | 4 | 3.86 | .350 | 1.55 | 9.3 | 4.8 | 10.8 | 30.1 | 31 | 15 | 13 | 2 | 16 | 36 | 0 | 2 | 1 | 0 | 0 | 2 | 2 | 3.27 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 2 | 0 | 0 | 0 | 0.00 | .143 | 0.50 | 0.0 | 4.5 | 4.5 | 2.0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 18 | 0 | 2 | 0 | 4.34 | .331 | 1.41 | 8.7 | 4.0 | 4.7 | 29.0 | 28 | 14 | 14 | 1 | 13 | 15 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.97 |