| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 7 | 12 | 3.28 | .254 | 0.98 | 7.3 | 1.6 | 8.5 | 172.2 | 139 | 64 | 63 | 15 | 31 | 163 | 2 | 0 | 0 | 1 | 17 | 6 | 0 | 2.88 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 24 | 24 | 5 | 9 | 5.16 | .328 | 1.46 | 9.8 | 3.3 | 8.1 | 162.1 | 177 | 94 | 93 | 26 | 60 | 146 | 0 | 0 | 0 | 0 | 10 | 1 | 6 | 4.41 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 24 | 24 | 10 | 11 | 4.39 | .319 | 1.39 | 9.3 | 3.3 | 4.3 | 192.2 | 198 | 95 | 94 | 26 | 70 | 91 | 8 | 0 | 0 | 2 | 12 | 3 | 2 | 4.95 |
| SP | Gooden, D.Gooden, Dwight # >> | 21 | 1985 | R | 68 | 23 | 23 | 7 | 10 | 5.05 | .342 | 1.53 | 8.9 | 4.9 | 6.6 | 148.0 | 147 | 86 | 83 | 14 | 80 | 108 | 3 | 0 | 0 | 0 | 11 | 4 | 4 | 4.47 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 61 | 0 | 3 | 4 | 3.88 | .328 | 1.45 | 9.8 | 3.4 | 10.2 | 69.2 | 75 | 30 | 30 | 7 | 26 | 78 | 0 | 8 | 4 | 0 | 0 | 1 | 5 | 3.23 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 52 | 0 | 4 | 6 | 3.97 | .342 | 1.51 | 9.3 | 4.3 | 7.2 | 59.0 | 61 | 26 | 26 | 5 | 28 | 47 | 0 | 5 | 6 | 0 | 0 | 3 | 2 | 4.08 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 69 | 35 | 0 | 4 | 4 | 2.45 | .250 | 0.98 | 6.1 | 2.7 | 6.8 | 44.0 | 30 | 12 | 12 | 3 | 13 | 33 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.34 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 11 | 0 | 1 | 1 | 3.46 | .291 | 1.23 | 7.6 | 3.5 | 4.2 | 13.0 | 11 | 5 | 5 | 0 | 5 | 6 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.23 |