| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 25 | 25 | 9 | 9 | 3.88 | .309 | 1.32 | 7.4 | 4.5 | 6.3 | 146.0 | 120 | 74 | 63 | 13 | 73 | 102 | 0 | 0 | 0 | 0 | 14 | 3 | 1 | 4.32 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 24 | 24 | 8 | 10 | 4.63 | .334 | 1.49 | 9.9 | 3.5 | 5.3 | 142.0 | 156 | 78 | 73 | 21 | 55 | 84 | 6 | 0 | 0 | 2 | 12 | 3 | 1 | 4.96 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 26 | 1986 | L | 10 | 24 | 24 | 9 | 9 | 5.74 | .338 | 1.52 | 10.1 | 3.6 | 5.6 | 136.1 | 153 | 89 | 87 | 16 | 54 | 85 | 3 | 0 | 0 | 1 | 9 | 2 | 7 | 4.51 |
| SP | Bunning, J.Bunning, Jim >> | 35 | 1966 | R | 33 | 24 | 23 | 7 | 9 | 5.64 | .346 | 1.58 | 11.0 | 3.3 | 5.4 | 129.1 | 157 | 81 | 81 | 24 | 47 | 78 | 0 | 0 | 0 | 0 | 8 | 1 | 0 | 5.33 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 97 | 59 | 0 | 4 | 7 | 4.06 | .316 | 1.34 | 6.7 | 5.4 | 9.9 | 62.0 | 46 | 28 | 28 | 4 | 37 | 68 | 0 | 24 | 4 | 0 | 0 | 3 | 1 | 3.58 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 66 | 0 | 5 | 1 | 3.58 | .336 | 1.51 | 8.5 | 5.1 | 9.7 | 73.0 | 69 | 32 | 29 | 4 | 41 | 79 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.27 |
| SU | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 63 | 0 | 2 | 3 | 4.32 | .310 | 1.31 | 7.5 | 4.3 | 6.9 | 77.0 | 64 | 37 | 37 | 12 | 37 | 59 | 0 | 1 | 6 | 0 | 0 | 3 | 0 | 5.05 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 55 | 0 | 3 | 2 | 3.18 | .289 | 1.19 | 5.5 | 5.3 | 8.3 | 73.2 | 45 | 26 | 26 | 6 | 43 | 67 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 4.08 |
| RP | Marshall, M.Marshall, Mike >> | 31 | 1974 | R | 2 | 46 | 0 | 5 | 2 | 5.98 | .378 | 1.82 | 12.4 | 4.0 | 4.3 | 81.1 | 112 | 54 | 54 | 12 | 36 | 39 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 5.30 |