| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 30 | 30 | 13 | 13 | 4.24 | .289 | 1.21 | 8.9 | 2.1 | 4.9 | 201.2 | 198 | 96 | 95 | 22 | 46 | 109 | 4 | 0 | 0 | 0 | 18 | 2 | 4 | 4.05 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 29 | 29 | 12 | 10 | 4.44 | .311 | 1.34 | 9.1 | 3.0 | 8.7 | 180.1 | 181 | 96 | 89 | 25 | 60 | 173 | 2 | 0 | 0 | 2 | 17 | 3 | 3 | 3.93 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 28 | 28 | 10 | 11 | 4.84 | .309 | 1.32 | 8.9 | 3.0 | 4.6 | 147.0 | 145 | 81 | 79 | 25 | 49 | 75 | 0 | 0 | 0 | 0 | 10 | 3 | 4 | 5.25 |
| SP | Marichal, J.Marichal, Juan † >> | 29 | 1966 | R | 76 | 27 | 27 | 15 | 8 | 5.43 | .314 | 1.36 | 9.7 | 2.5 | 5.3 | 184.0 | 199 | 113 | 111 | 35 | 52 | 108 | 6 | 0 | 0 | 0 | 9 | 2 | 3 | 5.18 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 55 | 0 | 2 | 6 | 4.59 | .305 | 1.27 | 8.3 | 3.2 | 6.9 | 51.0 | 47 | 30 | 26 | 8 | 18 | 39 | 0 | 28 | 6 | 0 | 0 | 2 | 1 | 4.69 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 58 | 0 | 0 | 3 | 4.45 | .331 | 1.43 | 8.7 | 4.4 | 9.6 | 60.2 | 58 | 34 | 30 | 7 | 29 | 64 | 0 | 2 | 7 | 0 | 0 | 3 | 0 | 3.98 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 73 | 0 | 2 | 2 | 4.14 | .343 | 1.55 | 10.5 | 3.5 | 9.6 | 74.0 | 86 | 36 | 34 | 11 | 29 | 79 | 0 | 0 | 2 | 0 | 0 | 1 | 5 | 4.01 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 55 | 0 | 2 | 1 | 4.12 | .339 | 1.48 | 8.3 | 5.2 | 9.2 | 54.2 | 50 | 25 | 25 | 10 | 31 | 55 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 5.26 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 77 | 0 | 4 | 3 | 4.28 | .297 | 1.27 | 7.2 | 4.3 | 9.1 | 69.1 | 55 | 33 | 33 | 10 | 33 | 70 | 0 | 0 | 1 | 0 | 0 | 0 | 6 | 4.29 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 46 | 0 | 2 | 1 | 4.38 | .324 | 1.42 | 9.2 | 3.7 | 9.4 | 49.1 | 50 | 24 | 24 | 3 | 20 | 51 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.00 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 9 | 0 | 0 | 1 | 14.54 | .490 | 2.88 | 23.6 | 4.5 | 9.0 | 8.2 | 21 | 15 | 14 | 7 | 4 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 13.88 |