| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 26 | 26 | 10 | 9 | 3.82 | .274 | 1.13 | 7.8 | 2.4 | 8.8 | 186.1 | 161 | 86 | 79 | 22 | 49 | 181 | 7 | 0 | 0 | 1 | 16 | 1 | 4 | 3.40 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 25 | 25 | 10 | 6 | 3.98 | .307 | 1.32 | 9.5 | 2.3 | 5.8 | 165.0 | 174 | 81 | 73 | 14 | 43 | 106 | 3 | 0 | 0 | 1 | 14 | 2 | 0 | 3.64 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 25 | 25 | 7 | 10 | 3.67 | .292 | 1.24 | 8.5 | 2.6 | 4.7 | 169.0 | 160 | 71 | 69 | 12 | 49 | 89 | 6 | 0 | 0 | 1 | 15 | 0 | 3 | 3.74 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 24 | 24 | 9 | 9 | 4.95 | .335 | 1.48 | 9.8 | 3.6 | 8.0 | 143.2 | 156 | 81 | 79 | 18 | 57 | 127 | 0 | 0 | 0 | 0 | 13 | 4 | 3 | 4.14 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 83 | 0 | 1 | 4 | 3.32 | .255 | 1.01 | 5.2 | 3.9 | 9.4 | 62.1 | 36 | 24 | 23 | 7 | 27 | 65 | 0 | 11 | 0 | 0 | 0 | 1 | 3 | 3.73 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 74 | 0 | 10 | 5 | 3.55 | .234 | 0.90 | 7.3 | 0.9 | 9.3 | 78.2 | 63 | 34 | 31 | 13 | 8 | 81 | 0 | 5 | 6 | 0 | 0 | 1 | 0 | 3.44 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 35 | 0 | 2 | 0 | 4.08 | .289 | 1.19 | 5.9 | 4.9 | 10.3 | 35.1 | 23 | 16 | 16 | 3 | 19 | 40 | 0 | 6 | 1 | 0 | 0 | 1 | 4 | 3.54 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 21 | 0 | 0 | 0 | 1.23 | .327 | 1.45 | 6.5 | 6.5 | 13.9 | 22.0 | 16 | 3 | 3 | 0 | 16 | 34 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.09 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 17 | 0 | 3 | 5 | 4.98 | .356 | 1.62 | 9.2 | 5.4 | 3.1 | 43.1 | 44 | 24 | 24 | 4 | 26 | 15 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 5.47 |