| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 29 | 29 | 12 | 6 | 4.11 | .302 | 1.30 | 8.8 | 2.9 | 9.1 | 168.2 | 165 | 81 | 77 | 19 | 54 | 170 | 0 | 0 | 0 | 0 | 18 | 0 | 0 | 3.41 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 27 | 27 | 12 | 10 | 4.88 | .317 | 1.36 | 9.3 | 2.9 | 5.0 | 164.0 | 170 | 89 | 89 | 15 | 53 | 92 | 3 | 0 | 0 | 1 | 12 | 5 | 5 | 4.13 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 27 | 27 | 10 | 11 | 3.79 | .272 | 1.11 | 7.7 | 2.4 | 6.1 | 180.2 | 153 | 78 | 76 | 17 | 48 | 122 | 8 | 0 | 0 | 2 | 15 | 2 | 5 | 3.71 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 45 | 0 | 0 | 4 | 3.44 | .270 | 1.11 | 7.7 | 2.4 | 10.7 | 49.2 | 42 | 20 | 19 | 6 | 13 | 58 | 0 | 23 | 4 | 0 | 0 | 0 | 1 | 3.02 |
| SU | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 57 | 0 | 6 | 0 | 3.55 | .296 | 1.22 | 6.9 | 4.1 | 7.6 | 63.1 | 48 | 25 | 25 | 7 | 29 | 53 | 0 | 2 | 1 | 0 | 0 | 3 | 4 | 4.29 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 32 | 0 | 3 | 2 | 4.19 | .352 | 1.57 | 6.9 | 7.4 | 9.0 | 34.1 | 26 | 16 | 16 | 4 | 28 | 34 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 5.18 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 42 | 0 | 0 | 4 | 5.03 | .353 | 1.61 | 9.6 | 5.1 | 12.0 | 48.1 | 51 | 27 | 27 | 4 | 27 | 64 | 0 | 0 | 1 | 0 | 0 | 1 | 5 | 3.17 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 36 | 0 | 3 | 1 | 3.06 | .273 | 1.09 | 7.1 | 2.7 | 6.5 | 47.0 | 37 | 16 | 16 | 3 | 14 | 34 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 3.40 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 7 | 1 | 0 | 0 | 6.75 | .362 | 1.70 | 12.9 | 3.2 | 6.4 | 14.2 | 20 | 11 | 11 | 2 | 5 | 10 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.50 |