| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 19 | 19 | 8 | 7 | 3.46 | .264 | 1.05 | 7.1 | 2.4 | 8.2 | 140.1 | 110 | 56 | 54 | 16 | 38 | 127 | 5 | 0 | 0 | 1 | 9 | 3 | 2 | 3.55 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 70 | 18 | 18 | 7 | 10 | 4.54 | .326 | 1.44 | 9.9 | 3.1 | 3.4 | 111.0 | 122 | 59 | 56 | 13 | 38 | 42 | 3 | 0 | 0 | 0 | 8 | 1 | 3 | 4.82 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 66 | 17 | 17 | 6 | 9 | 5.44 | .330 | 1.47 | 9.6 | 3.7 | 4.2 | 96.0 | 102 | 60 | 58 | 16 | 39 | 45 | 1 | 0 | 0 | 0 | 8 | 1 | 3 | 5.48 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 17 | 17 | 4 | 6 | 4.75 | .328 | 1.46 | 10.0 | 3.2 | 4.3 | 119.1 | 132 | 73 | 63 | 12 | 42 | 57 | 2 | 0 | 0 | 0 | 8 | 1 | 2 | 4.44 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 46 | 0 | 3 | 0 | 2.47 | .251 | 0.99 | 6.0 | 3.0 | 10.2 | 54.2 | 36 | 15 | 15 | 6 | 18 | 61 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.24 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 42 | 0 | 3 | 2 | 3.72 | .319 | 1.41 | 7.3 | 5.4 | 8.3 | 48.1 | 39 | 20 | 20 | 5 | 29 | 44 | 0 | 5 | 2 | 0 | 0 | 0 | 10 | 4.33 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 30 | 0 | 1 | 3 | 5.48 | .325 | 1.45 | 10.7 | 2.5 | 5.9 | 47.2 | 56 | 30 | 29 | 7 | 13 | 31 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 4.45 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 22 | 0 | 4 | 0 | 4.85 | .322 | 1.35 | 8.0 | 4.2 | 6.2 | 26.0 | 23 | 14 | 14 | 5 | 12 | 18 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5.73 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 12 | 0 | 0 | 2 | 4.91 | .389 | 1.82 | 11.5 | 4.9 | 8.2 | 11.0 | 14 | 6 | 6 | 2 | 6 | 10 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.45 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 14 | 0 | 0 | 0 | 1.88 | .338 | 1.47 | 9.6 | 3.9 | 8.4 | 14.1 | 15 | 3 | 3 | 2 | 6 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.50 |