| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 31 | 31 | 18 | 7 | 3.26 | .282 | 1.17 | 7.7 | 2.9 | 8.4 | 248.2 | 211 | 98 | 90 | 21 | 79 | 232 | 11 | 0 | 0 | 2 | 20 | 3 | 4 | 3.22 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 30 | 30 | 14 | 6 | 3.25 | .284 | 1.18 | 7.4 | 3.3 | 4.9 | 202.1 | 165 | 75 | 73 | 15 | 74 | 109 | 1 | 0 | 0 | 0 | 20 | 2 | 6 | 4.01 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 29 | 29 | 10 | 8 | 3.70 | .280 | 1.16 | 7.9 | 2.6 | 5.6 | 165.1 | 144 | 71 | 68 | 19 | 47 | 102 | 0 | 0 | 0 | 0 | 11 | 2 | 1 | 4.15 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 29 | 29 | 10 | 11 | 4.06 | .297 | 1.26 | 8.7 | 2.6 | 5.3 | 232.2 | 225 | 111 | 105 | 30 | 67 | 137 | 13 | 0 | 0 | 3 | 14 | 3 | 2 | 4.41 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 28 | 28 | 13 | 9 | 4.27 | .328 | 1.44 | 9.7 | 3.3 | 4.2 | 217.1 | 234 | 107 | 103 | 20 | 80 | 102 | 10 | 0 | 0 | 1 | 15 | 4 | 10 | 4.42 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 70 | 0 | 5 | 7 | 2.84 | .320 | 1.40 | 7.6 | 4.9 | 8.8 | 73.0 | 62 | 29 | 23 | 5 | 40 | 71 | 0 | 12 | 4 | 0 | 0 | 1 | 0 | 3.63 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 59 | 0 | 6 | 5 | 4.85 | .322 | 1.41 | 9.1 | 3.6 | 11.3 | 72.1 | 73 | 41 | 39 | 11 | 29 | 90 | 0 | 5 | 4 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 30 | 0 | 2 | 4 | 4.76 | .356 | 1.62 | 9.0 | 5.8 | 8.0 | 28.1 | 28 | 15 | 15 | 5 | 18 | 25 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 5.57 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 26 | 0 | 1 | 3 | 3.79 | .309 | 1.34 | 7.9 | 4.3 | 7.4 | 40.1 | 35 | 17 | 17 | 3 | 19 | 33 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.75 |