| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 31 | 31 | 10 | 15 | 4.37 | .301 | 1.28 | 8.6 | 3.0 | 8.9 | 206.0 | 196 | 107 | 100 | 23 | 68 | 203 | 8 | 0 | 0 | 2 | 14 | 2 | 7 | 3.50 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 31 | 31 | 18 | 7 | 2.87 | .271 | 1.09 | 6.3 | 3.5 | 5.5 | 203.2 | 143 | 69 | 65 | 10 | 78 | 124 | 2 | 0 | 0 | 2 | 21 | 6 | 3 | 3.66 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 30 | 30 | 7 | 13 | 7.35 | .388 | 1.88 | 12.0 | 5.0 | 4.2 | 145.2 | 194 | 134 | 119 | 23 | 80 | 68 | 1 | 0 | 0 | 0 | 9 | 3 | 0 | 5.84 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 30 | 30 | 9 | 16 | 4.68 | .333 | 1.49 | 9.6 | 3.8 | 5.6 | 188.1 | 200 | 109 | 98 | 25 | 80 | 118 | 8 | 0 | 0 | 2 | 14 | 2 | 4 | 4.78 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 70 | 0 | 3 | 3 | 3.45 | .291 | 1.23 | 7.4 | 3.7 | 5.8 | 94.0 | 77 | 40 | 36 | 8 | 39 | 61 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 4.05 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 60 | 0 | 8 | 5 | 3.75 | .273 | 1.11 | 7.8 | 2.3 | 10.0 | 72.0 | 62 | 32 | 30 | 9 | 18 | 80 | 0 | 4 | 4 | 0 | 0 | 1 | 3 | 3.19 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 48 | 0 | 1 | 0 | 3.44 | .326 | 1.45 | 6.2 | 6.9 | 7.4 | 52.1 | 36 | 22 | 20 | 6 | 40 | 43 | 0 | 5 | 1 | 0 | 0 | 0 | 2 | 5.15 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 38 | 0 | 1 | 2 | 4.44 | .324 | 1.39 | 8.4 | 4.3 | 9.6 | 46.2 | 43 | 24 | 23 | 4 | 22 | 49 | 0 | 1 | 0 | 0 | 0 | 2 | 5 | 3.57 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 2 | 0 | 1 | 0 | 0.00 | .182 | 0.67 | 3.0 | 3.0 | 4.5 | 6.0 | 2 | 0 | 0 | 0 | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 2 | 0 | 1 | 0 | 9.00 | .464 | 2.60 | 16.2 | 7.2 | 1.8 | 5.0 | 9 | 5 | 5 | 1 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.60 |