| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 18 | 18 | 4 | 6 | 5.07 | .315 | 1.36 | 9.1 | 3.1 | 7.1 | 103.0 | 104 | 60 | 58 | 12 | 36 | 81 | 2 | 0 | 0 | 0 | 8 | 2 | 1 | 4.05 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 18 | 18 | 5 | 6 | 5.42 | .340 | 1.52 | 10.3 | 3.4 | 5.2 | 103.0 | 118 | 69 | 62 | 21 | 39 | 60 | 2 | 0 | 0 | 1 | 7 | 2 | 3 | 5.68 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 17 | 17 | 9 | 5 | 4.35 | .298 | 1.26 | 8.0 | 3.3 | 4.5 | 113.2 | 101 | 60 | 55 | 15 | 42 | 57 | 2 | 0 | 0 | 0 | 9 | 2 | 3 | 4.88 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 56 | 0 | 0 | 3 | 2.80 | .270 | 1.07 | 7.1 | 2.6 | 9.9 | 74.0 | 58 | 24 | 23 | 10 | 21 | 81 | 0 | 5 | 2 | 0 | 0 | 3 | 4 | 3.54 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 38 | 0 | 5 | 2 | 2.39 | .261 | 1.06 | 6.6 | 2.9 | 9.9 | 49.0 | 36 | 14 | 13 | 2 | 16 | 54 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 2.31 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 29 | 0 | 5 | 0 | 3.31 | .303 | 1.25 | 6.9 | 4.4 | 9.5 | 35.1 | 27 | 16 | 13 | 5 | 17 | 37 | 0 | 1 | 3 | 0 | 0 | 2 | 1 | 4.37 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 30 | 0 | 1 | 2 | 3.52 | .299 | 1.23 | 8.1 | 3.1 | 5.2 | 38.1 | 34 | 15 | 15 | 7 | 13 | 22 | 0 | 3 | 2 | 0 | 0 | 2 | 1 | 5.42 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 25 | 0 | 1 | 1 | 2.43 | .282 | 1.18 | 6.8 | 4.1 | 7.9 | 40.2 | 30 | 11 | 11 | 2 | 18 | 35 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.25 |