| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 20 | 20 | 9 | 6 | 3.02 | .274 | 1.07 | 6.8 | 2.8 | 10.5 | 137.0 | 103 | 48 | 46 | 10 | 43 | 160 | 0 | 0 | 0 | 0 | 14 | 9 | 2 | 2.75 |
| SP | Pepiot, R.Pepiot, Ryan >> | 27 | 2025 | R | 78 | 19 | 19 | 4 | 8 | 6.22 | .359 | 1.64 | 9.7 | 5.1 | 9.6 | 101.1 | 109 | 70 | 70 | 21 | 57 | 108 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 5.38 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 65 | 19 | 19 | 4 | 5 | 6.46 | .400 | 1.96 | 10.4 | 7.2 | 8.3 | 92.0 | 106 | 71 | 66 | 17 | 74 | 85 | 0 | 0 | 0 | 0 | 4 | 4 | 6 | 6.10 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 58 | 19 | 19 | 3 | 4 | 4.55 | .350 | 1.58 | 10.1 | 4.1 | 8.8 | 83.0 | 93 | 44 | 42 | 10 | 38 | 81 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 4.10 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 91 | 50 | 0 | 3 | 1 | 2.67 | .314 | 1.33 | 6.3 | 5.7 | 10.3 | 54.0 | 38 | 17 | 16 | 7 | 34 | 62 | 0 | 6 | 3 | 0 | 0 | 2 | 0 | 4.39 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 64 | 0 | 4 | 0 | 3.30 | .271 | 1.10 | 6.0 | 3.9 | 8.0 | 60.0 | 40 | 24 | 22 | 6 | 26 | 53 | 0 | 0 | 3 | 0 | 0 | 1 | 6 | 3.88 |
| RP | Banks, T.Banks, Tanner >> | 33 | 2025 | L | 71 | 57 | 0 | 3 | 2 | 2.77 | .284 | 1.14 | 7.9 | 2.5 | 9.2 | 55.1 | 48 | 17 | 17 | 3 | 15 | 56 | 0 | 1 | 0 | 0 | 0 | 3 | 4 | 2.65 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 53 | 0 | 5 | 2 | 3.38 | .314 | 1.33 | 8.4 | 3.6 | 9.4 | 48.0 | 45 | 20 | 18 | 10 | 19 | 50 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 4.94 |
| SP | Peralta, F.Peralta, Freddy >> | 29 | 2025 | R | 88 | 14 | 0 | 2 | 2 | 2.30 | .319 | 1.34 | 9.6 | 3.0 | 13.8 | 15.2 | 16 | 4 | 4 | 2 | 5 | 23 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 2.87 |