| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 20 | 20 | 8 | 7 | 3.31 | .306 | 1.30 | 9.2 | 2.5 | 10.2 | 130.1 | 133 | 52 | 48 | 12 | 36 | 148 | 0 | 0 | 0 | 0 | 14 | 3 | 1 | 2.82 |
| SP | Gausman, K.Gausman, Kevin # >> | 34 | 2025 | R | 81 | 19 | 19 | 8 | 7 | 4.82 | .309 | 1.32 | 8.7 | 3.2 | 9.3 | 114.0 | 110 | 64 | 61 | 18 | 41 | 118 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 4.11 |
| SP | Horton, C.Horton, Cade >> | 23 | 2025 | R | 75 | 19 | 19 | 3 | 8 | 4.88 | .308 | 1.32 | 9.5 | 2.5 | 7.0 | 99.2 | 105 | 57 | 54 | 19 | 27 | 77 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 4.79 |
| SP | Imanaga, S.Imanaga, Shota † >> | 31 | 2025 | L | 79 | 19 | 18 | 9 | 2 | 3.12 | .259 | 1.01 | 7.3 | 1.8 | 7.7 | 118.1 | 96 | 44 | 41 | 13 | 23 | 101 | 0 | 0 | 0 | 0 | 12 | 5 | 3 | 3.43 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 88 | 35 | 0 | 0 | 2 | 2.94 | .257 | 1.04 | 6.3 | 3.3 | 7.6 | 33.2 | 23 | 11 | 11 | 1 | 12 | 28 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 2.79 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 74 | 40 | 0 | 6 | 1 | 3.95 | .255 | 1.00 | 4.8 | 4.2 | 6.1 | 41.0 | 22 | 18 | 18 | 4 | 19 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.37 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 68 | 17 | 0 | 0 | 1 | 6.35 | .378 | 1.82 | 13.8 | 2.6 | 7.4 | 17.0 | 26 | 12 | 12 | 1 | 5 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 67 | 18 | 0 | 0 | 1 | 4.24 | .338 | 1.53 | 10.1 | 3.7 | 5.8 | 17.0 | 19 | 8 | 8 | 2 | 7 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.47 |
| SP | Suarez, R.Suarez, Ranger >> | 29 | 2025 | L | 46 | 12 | 0 | 1 | 1 | 5.94 | .400 | 1.91 | 11.9 | 5.4 | 7.3 | 47.0 | 62 | 43 | 31 | 11 | 28 | 38 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 6.47 |