| SP | Peavy, J.Peavy, Jake # >> | 24 | 2005 | R | 95 | 26 | 26 | 13 | 10 | 3.08 | .293 | 1.22 | 8.3 | 2.7 | 8.7 | 187.0 | 172 | 68 | 64 | 7 | 56 | 181 | 4 | 0 | 0 | 2 | 18 | 4 | 0 | 2.51 |
| SP | Zambrano, C.Zambrano, Carlos >> | 27 | 2008 | R | 57 | 25 | 25 | 11 | 8 | 4.25 | .326 | 1.44 | 8.9 | 4.0 | 4.4 | 165.0 | 164 | 80 | 78 | 13 | 74 | 81 | 2 | 0 | 0 | 1 | 13 | 1 | 3 | 4.41 |
| SP | Williams, T.Williams, Trevor >> | 25 | 2017 | R | 50 | 24 | 24 | 7 | 9 | 5.31 | .345 | 1.56 | 10.8 | 3.2 | 5.9 | 117.0 | 140 | 74 | 69 | 10 | 42 | 77 | 0 | 0 | 0 | 0 | 4 | 3 | 4 | 3.95 |
| SP | Raffensberger, K.Raffensberger, Ken >> | 32 | 1949 | L | 41 | 24 | 24 | 8 | 11 | 5.34 | .351 | 1.62 | 11.0 | 3.6 | 3.3 | 151.2 | 185 | 94 | 90 | 14 | 60 | 56 | 1 | 0 | 0 | 0 | 11 | 1 | 0 | 4.68 |
| RP | Orosco, J.Orosco, Jesse >> | 40 | 1997 | L | 82 | 57 | 0 | 5 | 1 | 3.11 | .294 | 1.19 | 6.2 | 4.6 | 5.2 | 75.1 | 52 | 30 | 26 | 4 | 38 | 43 | 0 | 6 | 2 | 0 | 0 | 4 | 1 | 4.23 |
| RP | Brantley, J.Brantley, Jeff # >> | 27 | 1990 | R | 57 | 55 | 0 | 3 | 6 | 5.15 | .337 | 1.50 | 8.9 | 4.7 | 5.9 | 73.1 | 72 | 46 | 42 | 7 | 38 | 48 | 0 | 8 | 6 | 0 | 0 | 2 | 0 | 4.58 |
| RP | Petkovsek, M.Petkovsek, Mark >> | 34 | 1999 | R | 41 | 48 | 0 | 2 | 1 | 2.63 | .297 | 1.27 | 8.5 | 3.0 | 3.9 | 51.1 | 48 | 17 | 15 | 3 | 17 | 22 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 3.90 |
| RP | Leone, D.Leone, Dominic >> | 27 | 2019 | R | 30 | 27 | 0 | 4 | 1 | 3.82 | .349 | 1.61 | 10.6 | 3.8 | 8.7 | 33.0 | 39 | 15 | 14 | 2 | 14 | 32 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 3.12 |
| SP | Lyles, J.Lyles, Jordan >> | 30 | 2021 | R | 30 | 1 | 0 | 0 | 1 | 20.25 | .529 | 3.38 | 27.0 | 13.5 | 4.5 | 2.2 | 6 | 6 | 6 | 1 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13.00 |
| SP | Ishii, K.Ishii, Kazuhisa >> | 31 | 2004 | L | 40 | 13 | 0 | 1 | 1 | 4.41 | .395 | 1.96 | 10.1 | 7.9 | 3.9 | 16.1 | 18 | 9 | 8 | 1 | 14 | 7 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 5.56 |