| SP | Wacha, M.Wacha, Michael >> | 30 | 2022 | R | 86 | 25 | 25 | 8 | 9 | 5.59 | .336 | 1.51 | 10.8 | 2.8 | 6.4 | 124.0 | 149 | 77 | 77 | 14 | 38 | 88 | 0 | 0 | 0 | 0 | 6 | 1 | 7 | 3.99 |
| SP | Niekro, J.Niekro, Joe # >> | 37 | 1981 | R | 69 | 25 | 25 | 9 | 11 | 3.66 | .301 | 1.27 | 7.8 | 3.6 | 5.3 | 169.2 | 147 | 74 | 69 | 8 | 68 | 99 | 4 | 0 | 0 | 1 | 14 | 4 | 10 | 3.72 |
| SP | Spahn, W.Spahn, Warren >> | 39 | 1960 | L | 64 | 25 | 25 | 8 | 8 | 4.69 | .313 | 1.34 | 9.6 | 2.4 | 5.3 | 155.1 | 166 | 83 | 81 | 7 | 42 | 92 | 3 | 0 | 0 | 1 | 13 | 4 | 3 | 3.29 |
| SP | Donohue, P.Donohue, Pete >> | 25 | 1925 | R | 51 | 24 | 24 | 8 | 8 | 4.78 | .309 | 1.33 | 9.5 | 2.6 | 4.2 | 148.2 | 156 | 98 | 79 | 10 | 42 | 69 | 5 | 0 | 0 | 0 | 12 | 1 | 0 | 3.82 |
| RP | Miller, A.Miller, Andrew † >> | 31 | 2016 | L | 99 | 79 | 0 | 8 | 3 | 2.95 | .283 | 1.16 | 7.9 | 2.6 | 8.7 | 103.2 | 90 | 34 | 34 | 10 | 30 | 100 | 0 | 7 | 3 | 0 | 0 | 3 | 0 | 3.28 |
| RP | Mota, G.Mota, Guillermo >> | 31 | 2004 | R | 77 | 65 | 0 | 2 | 2 | 3.08 | .338 | 1.53 | 9.5 | 4.3 | 6.0 | 87.2 | 92 | 30 | 30 | 6 | 42 | 58 | 0 | 12 | 0 | 0 | 0 | 0 | 3 | 4.01 |
| RP | Timlin, M.Timlin, Mike >> | 41 | 2007 | R | 75 | 59 | 0 | 3 | 6 | 3.95 | .329 | 1.44 | 10.2 | 3.0 | 5.3 | 70.2 | 79 | 35 | 31 | 6 | 23 | 41 | 0 | 6 | 4 | 0 | 0 | 2 | 0 | 4.01 |
| RP | McDowell, R.McDowell, Roger >> | 26 | 1986 | R | 69 | 49 | 0 | 9 | 2 | 2.57 | .274 | 1.13 | 6.9 | 3.3 | 5.3 | 77.0 | 59 | 22 | 22 | 4 | 28 | 45 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 3.60 |
| RP | Marshall, M.Marshall, Mike >> | 35 | 1978 | R | 68 | 36 | 0 | 1 | 3 | 3.88 | .295 | 1.20 | 7.1 | 3.7 | 3.7 | 53.1 | 42 | 27 | 23 | 5 | 22 | 22 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 4.81 |