| SP | Darvish, Y.Darvish, Yu # >> | 35 | 2022 | R | 79 | 22 | 22 | 7 | 8 | 4.24 | .293 | 1.22 | 9.1 | 1.9 | 8.8 | 146.1 | 147 | 74 | 69 | 13 | 31 | 143 | 0 | 0 | 0 | 0 | 12 | 4 | 0 | 2.92 |
| SP | Lamet, D.Lamet, Dinelson >> | 27 | 2020 | R | 100 | 23 | 22 | 1 | 1 | 2.17 | .307 | 1.31 | 8.1 | 3.7 | 8.1 | 58.0 | 52 | 17 | 14 | 2 | 24 | 52 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.95 |
| SP | Pivetta, N.Pivetta, Nick >> | 32 | 2025 | R | 78 | 22 | 21 | 10 | 4 | 4.46 | .302 | 1.28 | 9.1 | 2.5 | 8.3 | 133.1 | 134 | 72 | 66 | 18 | 37 | 122 | 1 | 0 | 0 | 1 | 9 | 2 | 3 | 3.80 |
| SP | Paddack, C.Paddack, Chris >> | 23 | 2019 | R | 72 | 21 | 21 | 10 | 8 | 4.17 | .319 | 1.37 | 9.3 | 3.1 | 6.4 | 123.0 | 127 | 63 | 57 | 16 | 42 | 88 | 0 | 0 | 0 | 0 | 10 | 4 | 2 | 4.38 |
| SP | Dravecky, D.Dravecky, Dave >> | 26 | 1982 | L | 58 | 21 | 21 | 0 | 5 | 5.31 | .329 | 1.41 | 9.0 | 3.8 | 4.7 | 79.2 | 79 | 48 | 47 | 10 | 33 | 41 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 5.05 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 64 | 0 | 12 | 1 | 1.71 | .231 | 0.87 | 5.9 | 1.9 | 8.8 | 84.1 | 55 | 20 | 16 | 5 | 18 | 82 | 0 | 4 | 0 | 0 | 0 | 3 | 2 | 2.57 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 97 | 59 | 0 | 6 | 2 | 2.85 | .276 | 1.14 | 5.8 | 4.6 | 9.5 | 72.2 | 46 | 23 | 23 | 5 | 37 | 76 | 0 | 4 | 3 | 0 | 0 | 0 | 3 | 3.33 |
| RP | Meredith, C.Meredith, Cla >> | 23 | 2006 | R | 82 | 62 | 0 | 6 | 3 | 3.33 | .245 | 0.93 | 7.0 | 1.4 | 6.3 | 73.0 | 57 | 27 | 27 | 6 | 11 | 51 | 0 | 6 | 5 | 0 | 0 | 3 | 0 | 3.25 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 94 | 52 | 0 | 4 | 1 | 3.75 | .281 | 1.17 | 7.9 | 2.7 | 7.0 | 50.1 | 44 | 21 | 21 | 3 | 15 | 39 | 0 | 3 | 2 | 0 | 0 | 0 | 4 | 3.12 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 79 | 34 | 0 | 4 | 2 | 3.54 | .278 | 1.16 | 7.7 | 2.9 | 8.3 | 40.2 | 34 | 16 | 16 | 3 | 13 | 37 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 3.10 |
| RP | Thatcher, J.Thatcher, Joe >> | 29 | 2010 | L | 72 | 75 | 0 | 3 | 2 | 1.78 | .280 | 1.15 | 7.4 | 3.1 | 8.3 | 55.2 | 45 | 11 | 11 | 3 | 19 | 51 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 2.95 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 69 | 59 | 0 | 4 | 3 | 3.92 | .285 | 1.20 | 7.3 | 3.5 | 7.2 | 64.1 | 52 | 28 | 28 | 6 | 25 | 51 | 0 | 6 | 2 | 0 | 0 | 0 | 2 | 3.80 |