| SP | Jimenez, U.Jimenez, Ubaldo >> | 26 | 2010 | R | 64 | 22 | 22 | 12 | 6 | 4.16 | .319 | 1.41 | 7.9 | 4.7 | 5.5 | 145.0 | 128 | 70 | 67 | 16 | 76 | 88 | 3 | 0 | 0 | 0 | 12 | 0 | 6 | 4.79 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 46 | 22 | 22 | 8 | 3 | 4.82 | .353 | 1.62 | 9.7 | 4.9 | 7.1 | 108.1 | 116 | 60 | 58 | 10 | 59 | 85 | 0 | 0 | 0 | 0 | 4 | 2 | 4 | 4.32 |
| SP | Gomber, A.Gomber, Austin >> | 27 | 2021 | L | 45 | 21 | 21 | 6 | 5 | 4.77 | .352 | 1.63 | 10.3 | 4.5 | 6.1 | 103.2 | 118 | 56 | 55 | 9 | 51 | 70 | 0 | 0 | 0 | 0 | 6 | 0 | 1 | 4.26 |
| SP | Marquez, G.Marquez, German † # >> | 23 | 2018 | R | 51 | 21 | 21 | 14 | 2 | 4.00 | .304 | 1.30 | 8.9 | 2.7 | 8.3 | 135.0 | 134 | 63 | 60 | 15 | 41 | 125 | 1 | 0 | 0 | 0 | 13 | 2 | 4 | 3.55 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 70 | 57 | 0 | 7 | 2 | 2.25 | .227 | 0.88 | 4.9 | 3.0 | 10.3 | 84.0 | 46 | 23 | 21 | 7 | 28 | 96 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 2.80 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 61 | 57 | 0 | 3 | 3 | 4.44 | .330 | 1.45 | 10.3 | 2.8 | 8.5 | 71.0 | 81 | 37 | 35 | 8 | 22 | 67 | 0 | 8 | 2 | 0 | 0 | 2 | 0 | 3.59 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 53 | 45 | 0 | 3 | 2 | 3.16 | .280 | 1.13 | 7.8 | 2.5 | 6.4 | 51.1 | 44 | 20 | 18 | 7 | 14 | 36 | 0 | 6 | 1 | 0 | 0 | 2 | 0 | 4.31 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 59 | 28 | 0 | 0 | 2 | 3.42 | .282 | 1.18 | 7.3 | 3.5 | 5.9 | 26.1 | 21 | 10 | 10 | 3 | 10 | 17 | 0 | 7 | 0 | 0 | 0 | 0 | 2 | 4.35 |