| SP | Martinez, P.Martinez, Pedro † # >> | 26 | 1997 | R | 92 | 37 | 37 | 19 | 13 | 3.23 | .290 | 1.20 | 7.7 | 3.1 | 9.2 | 267.1 | 229 | 100 | 96 | 24 | 93 | 273 | 8 | 0 | 0 | 2 | 25 | 5 | 2 | 3.22 |
| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 97 | 36 | 36 | 16 | 11 | 3.36 | .284 | 1.18 | 7.9 | 2.8 | 8.6 | 222.0 | 194 | 88 | 83 | 15 | 69 | 212 | 0 | 0 | 0 | 0 | 21 | 1 | 0 | 2.91 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 76 | 34 | 34 | 11 | 11 | 5.53 | .355 | 1.65 | 11.0 | 3.9 | 5.7 | 198.2 | 241 | 126 | 122 | 29 | 86 | 125 | 1 | 0 | 0 | 0 | 15 | 1 | 3 | 4.96 |
| SP | Strasburg, S.Strasburg, Stephen # >> | 24 | 2013 | R | 49 | 34 | 34 | 5 | 11 | 5.72 | .341 | 1.55 | 9.7 | 4.2 | 8.3 | 148.0 | 160 | 101 | 94 | 17 | 69 | 136 | 0 | 0 | 0 | 0 | 6 | 1 | 4 | 4.07 |
| SP | Bottenfield, K.Bottenfield, Kent >> | 24 | 1992 | R | 23 | 33 | 31 | 2 | 5 | 5.18 | .347 | 1.57 | 10.6 | 3.6 | 5.2 | 97.1 | 114 | 60 | 56 | 7 | 39 | 56 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4.05 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 97 | 85 | 0 | 5 | 6 | 2.65 | .247 | 0.95 | 6.7 | 1.9 | 10.1 | 98.2 | 73 | 31 | 29 | 8 | 21 | 110 | 0 | 37 | 2 | 0 | 0 | 3 | 1 | 2.55 |
| RP | Reardon, J.Reardon, Jeff † >> | 26 | 1981 | R | 89 | 102 | 0 | 17 | 8 | 3.35 | .302 | 1.28 | 6.6 | 5.0 | 5.2 | 158.2 | 116 | 64 | 59 | 15 | 87 | 91 | 0 | 7 | 2 | 0 | 0 | 3 | 10 | 4.79 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 70 | 92 | 0 | 7 | 6 | 3.29 | .269 | 1.07 | 7.1 | 2.6 | 7.8 | 125.2 | 98 | 48 | 46 | 13 | 36 | 109 | 0 | 3 | 4 | 0 | 0 | 5 | 0 | 3.59 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 77 | 73 | 0 | 4 | 3 | 3.84 | .310 | 1.35 | 7.8 | 4.4 | 7.8 | 86.2 | 75 | 38 | 37 | 8 | 42 | 75 | 0 | 2 | 3 | 0 | 0 | 0 | 3 | 3.93 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 57 | 60 | 0 | 6 | 1 | 4.62 | .308 | 1.33 | 9.1 | 2.9 | 9.9 | 78.0 | 79 | 44 | 40 | 12 | 25 | 86 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.76 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 34 | 61 | 0 | 4 | 1 | 1.78 | .279 | 1.12 | 6.8 | 3.3 | 4.0 | 70.2 | 53 | 15 | 14 | 7 | 26 | 31 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 4.66 |