| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 92 | 10 | 10 | 4 | 5 | 5.13 | .351 | 1.58 | 9.9 | 4.4 | 7.8 | 59.2 | 65 | 34 | 34 | 5 | 29 | 51 | 1 | 0 | 0 | 0 | 5 | 3 | 1 | 4.00 |
| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 97 | 10 | 10 | 6 | 4 | 4.01 | .294 | 1.23 | 8.2 | 2.9 | 9.6 | 58.1 | 53 | 26 | 26 | 6 | 19 | 62 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 3.24 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 75 | 10 | 10 | 5 | 1 | 5.13 | .347 | 1.58 | 11.3 | 3.1 | 5.5 | 59.2 | 74 | 34 | 34 | 11 | 20 | 36 | 1 | 0 | 0 | 0 | 4 | 1 | 1 | 5.27 |
| SP | Strasburg, S.Strasburg, Stephen >> | 24 | 2013 | R | 46 | 10 | 10 | 1 | 3 | 5.44 | .329 | 1.47 | 10.0 | 3.3 | 7.6 | 46.1 | 51 | 32 | 28 | 8 | 17 | 39 | 0 | 0 | 0 | 0 | 3 | 0 | 3 | 4.67 |
| SP | Bottenfield, K.Bottenfield, Kent >> | 24 | 1992 | R | 25 | 11 | 10 | 0 | 2 | 4.03 | .341 | 1.48 | 10.2 | 3.1 | 7.1 | 29.0 | 33 | 14 | 13 | 1 | 10 | 23 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.10 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 97 | 28 | 0 | 3 | 2 | 4.11 | .270 | 1.08 | 8.1 | 1.8 | 11.7 | 30.2 | 27 | 16 | 14 | 5 | 6 | 39 | 0 | 12 | 1 | 0 | 0 | 1 | 0 | 3.27 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 89 | 31 | 0 | 5 | 2 | 2.63 | .270 | 1.11 | 5.8 | 4.2 | 4.4 | 51.1 | 33 | 19 | 15 | 4 | 24 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 4.45 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 70 | 28 | 0 | 3 | 2 | 3.32 | .260 | 1.03 | 6.4 | 2.8 | 7.8 | 38.0 | 27 | 14 | 14 | 3 | 12 | 33 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.32 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 77 | 21 | 0 | 1 | 0 | 6.26 | .344 | 1.57 | 9.3 | 5.0 | 7.3 | 27.1 | 28 | 19 | 19 | 5 | 15 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 5.44 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 57 | 20 | 0 | 1 | 0 | 6.66 | .342 | 1.56 | 10.9 | 3.4 | 11.3 | 24.1 | 29 | 21 | 18 | 6 | 9 | 30 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 34 | 19 | 0 | 0 | 0 | 3.38 | .308 | 1.29 | 6.8 | 4.9 | 3.0 | 24.0 | 18 | 10 | 9 | 4 | 13 | 8 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 6.25 |