| SP | Adams, B.Adams, Babe † >> | 37 | 1919 | R | 77 | 34 | 34 | 15 | 13 | 4.05 | .287 | 1.18 | 9.1 | 1.6 | 3.9 | 255.2 | 257 | 118 | 115 | 19 | 44 | 111 | 13 | 0 | 0 | 4 | 16 | 7 | 3 | 3.70 |
| SP | Cooper, W.Cooper, Wilbur >> | 25 | 1917 | L | 46 | 33 | 33 | 13 | 14 | 4.53 | .326 | 1.43 | 10.0 | 2.9 | 5.0 | 218.2 | 242 | 115 | 110 | 17 | 71 | 122 | 6 | 0 | 0 | 2 | 17 | 4 | 5 | 3.93 |
| SP | Skenes, P.Skenes, Paul # >> | 23 | 2025 | R | 86 | 32 | 31 | 11 | 10 | 4.72 | .305 | 1.28 | 9.1 | 2.5 | 8.3 | 194.2 | 196 | 103 | 102 | 23 | 53 | 178 | 0 | 0 | 0 | 0 | 15 | 7 | 1 | 3.63 |
| SP | Tannehill, J.Tannehill, Jesse >> | 28 | 1902 | L | 59 | 30 | 30 | 15 | 11 | 4.19 | .313 | 1.35 | 10.0 | 2.2 | 5.1 | 215.0 | 239 | 106 | 100 | 28 | 52 | 122 | 5 | 0 | 0 | 1 | 18 | 3 | 0 | 4.33 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 60 | 59 | 0 | 6 | 1 | 2.07 | .254 | 1.02 | 6.9 | 2.3 | 9.7 | 69.2 | 53 | 17 | 16 | 3 | 18 | 74 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 2.20 |
| RP | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 67 | 41 | 0 | 4 | 0 | 3.12 | .272 | 1.10 | 7.7 | 2.2 | 6.6 | 49.0 | 42 | 17 | 17 | 4 | 12 | 36 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.39 |
| RP | Rodriguez, R.Rodriguez, Richard >> | 31 | 2021 | R | 67 | 40 | 0 | 4 | 4 | 4.95 | .337 | 1.53 | 11.0 | 2.7 | 6.3 | 40.0 | 49 | 22 | 22 | 2 | 12 | 28 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.15 |
| RP | Watson, T.Watson, Tony >> | 30 | 2015 | L | 45 | 19 | 0 | 1 | 2 | 4.42 | .313 | 1.36 | 10.5 | 2.0 | 7.5 | 18.1 | 21 | 9 | 9 | 4 | 4 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.89 |
| RP | Blanton, J.Blanton, Joe >> | 35 | 2015 | R | 41 | 32 | 0 | 0 | 1 | 3.63 | .325 | 1.41 | 8.7 | 4.2 | 6.6 | 34.2 | 33 | 14 | 14 | 2 | 16 | 25 | 0 | 3 | 7 | 0 | 0 | 1 | 3 | 3.79 |
| CL | Melancon, M.Melancon, Mark >> | 30 | 2015 | R | 50 | 47 | 0 | 1 | 4 | 3.83 | .266 | 1.09 | 6.9 | 3.0 | 6.0 | 42.1 | 32 | 18 | 18 | 5 | 14 | 28 | 0 | 39 | 6 | 0 | 0 | 0 | 1 | 4.21 |
| SP | Drabek, D.Drabek, Doug >> | 28 | 1990 | R | 58 | 29 | 22 | 6 | 9 | 6.64 | .386 | 1.85 | 13.0 | 3.7 | 5.1 | 142.1 | 205 | 113 | 105 | 20 | 59 | 81 | 0 | 0 | 0 | 0 | 10 | 5 | 4 | 5.04 |